Mode of action of alginic acid compound in the reduction of gastroesophageal reflux. [Sr-87m, Tc-99m]

Journal Article · Mon Oct 01 04:00:00 EDT 1979 · J. Nucl. Med.; (United States)

OSTI ID:5707147

Malmud, L S; Charkes, N D; Littlefield, J; Reilley, J; Stern, H; Rosenberg, R; Fisher, R S

This study was designed to evaluate quantitatively the mode of action of alginic acid compound (AAC) in the treatment of patients with symptomatic gastroesophageal reflux. Gastroesophageal scintigraphy using an orally administered Tc-99m sulfur colloid solution was used to demonstrate that AAC decreased significantly the gastroesophageal reflux index from (9.9 +- 1.3)% to (6.5 +- 0.8)% (p < 0.05). No alteration of lower esophageal sphincter pressure was observed. After AAC was suitably labeled with Sr-87m, a dual-nuclide scintigraphic technique was used to show that most (< 75%) of the AAC was located in the upper half of the stomach in both normal subjects and patients with gastroesophageal reflux. In those subjects in whom reflux did occur after treatment with AAC, the Sr-87m-AAC refluxed into the esophagus preferentially compared with the liquid containing Tc-99m sulfur colloid. These findings suggest that AAC diminishes gastroesophageal reflux by means of its foaming, floating, and viscous properties.

• Research Organization: Temple Univ., Philadelphia, PA
• OSTI ID: 5707147
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 20:10; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ALGINATES
ALKALINE EARTH ISOTOPES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL LOCALIZATION
BODY
COLLOIDS
COMPLEXES
COUNTING TECHNIQUES
DATA
DATA FORMS
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DIGESTIVE SYSTEM DISEASES
DISEASES
DISPERSIONS
DUAL-ISOTOPE SUBTRACTION TECHNIQUE
ELECTRON CAPTURE RADIOISOTOPES
ESOPHAGUS
EVEN-ODD NUCLEI
EXPERIMENTAL DATA
GASTROINTESTINAL TRACT
HOURS LIVING RADIOISOTOPES
INFORMATION
INTERMEDIATE MASS NUCLEI
ISOLATED VALUES
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANS
PATIENTS
RADIOCOLLOIDS
RADIOISOTOPE SCANNING
RADIOISOTOPES
SCINTISCANNING
STABLE ISOTOPES
STOMACH
STRONTIUM 87
STRONTIUM ISOTOPES
SULFUR COMPLEXES
TECHNETIUM 99
TECHNETIUM ISOTOPES
TRACER TECHNIQUES
YEARS LIVING RADIOISOTOPES