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Transformation of mouse C3H/10T 1/2 cells by single and fractionated doses of x rays and fission-spectrum neutrons

Journal Article · · Cancer Res.; (United States)
OSTI ID:7098298
;
A mouse embryo-derived cell line, C3H/10T 1/2, was used to measure the frequency of in vitro neoplastic transformation induced by 50-kVp x rays and by fission-spectrum neutrons from the JANUS reactor at the Argonne National Laboratory. The transformation frequency after single x-ray doses rises exponentially, reaching a plateau at about 3 x 10/sup -3/ transformant/survivor. The induction curve following single neutron doses, while qualitatively similar, initially rises more steeply and levels off at a maximum of about 6 x 10/sup -3/ transformant/survivor. Fractionation of a total x-ray dose of 700 rads results in an approximately 6-fold increase in survival and reduction in transformation frequency over a 16-hr interval. Fractionation of the total neutron dose of 378 rads has no effect upon cell survival, and transformation frequency declines by a factor of only about 1.7 at most over a 24-hr period. Cells derived from transformed foci formed fibrosarcomas when injected into appropriately treated mice.
Research Organization:
Argonne National Lab., IL
OSTI ID:
7098298
Journal Information:
Cancer Res.; (United States), Journal Name: Cancer Res.; (United States) Vol. 39; ISSN CNREA
Country of Publication:
United States
Language:
English

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Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BARYONS
COMPARATIVE EVALUATIONS
DISEASES
ELECTROMAGNETIC RADIATION
ELEMENTARY PARTICLES
ENRICHED URANIUM REACTORS
FERMIONS
FIBROSARCOMAS
FISSION NEUTRONS
FRACTIONATED IRRADIATION
HADRONS
IN VITRO
IONIZING RADIATIONS
IRRADIATION
JANUS REACTOR
MAMMALS
MICE
NEOPLASMS
NEUTRONS
NUCLEONS
ONCOGENIC TRANSFORMATIONS
RADIATIONS
REACTORS
RESEARCH AND TEST REACTORS
RESEARCH REACTORS
RODENTS
SARCOMAS
SOFT X RADIATION
SURVIVAL CURVES
TANK TYPE REACTORS
THERMAL REACTORS
VERTEBRATES
WATER COOLED REACTORS
WATER MODERATED REACTORS
X RADIATION