Absence of a dose-fractionation effect on neoplastic transformation induced by fission-spectrum neutrons in C3H 10T1/2 cells

Journal Article · Sat Jun 01 04:00:00 EDT 1991 · Radiation Research; (USA)

DOI:https://doi.org/10.2307/3577924· OSTI ID:5544802

Saran, A; Pazzaglia, S; Coppola, M; Rebessi, S; Di Majo, V; Garavini, M; Covelli, V ^[1]

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1. ENEA, Rome (Italy)

We have investigated the effect of fission-spectrum neutron dose fractionation on neoplastic transformation of exponentially growing C3H 10T1/2 cells. Total doses of 10.8, 27, 54, and 108 cGy were given in single doses or in five equal fractions delivered at 24-h intervals in the biological channel of the RSV-TAPIRO reactor at CRE-Casaccia. Both cell inactivation and neoplastic transformation were more effectively induced by fission neutrons than by 250-kVp X rays. No significant effect on cell survival or neoplastic transformation was observed with split doses compared to single doses of fission-spectrum neutrons. Neutron RBE values relative to X rays determined from data for survival and neoplastic transformation were comparable.

• OSTI ID: 5544802
• Journal Information: Radiation Research; (USA), Journal Name: Radiation Research; (USA) Vol. 126:3; ISSN 0033-7587; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560120* -- Radiation Effects on Biochemicals
Cells
& Tissue Culture
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BARYONS
CELL TRANSFORMATIONS
COMPARATIVE EVALUATIONS
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
ELEMENTARY PARTICLES
EVALUATION
FERMIONS
FISSION NEUTRONS
FRACTIONATED IRRADIATION
HADRONS
IONIZING RADIATIONS
IRRADIATION
NEUTRONS
NUCLEONS
ONCOGENIC TRANSFORMATIONS
RADIATIONS
RADIOINDUCTION
RBE
SURVIVAL TIME
X RADIATION