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Neoplastic transformation is enhanced by multiple low doses of fission-spectrum neutrons

Journal Article · · Radiat. Res.; (United States)
DOI:https://doi.org/10.2307/3576716· OSTI ID:5517839
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The neoplastic transformation of C3H mouse 10T1/2 cells was measured induced by fission-spectrum neutrons delivered at a high dose rate in five fractions over 4 days. The transformation frequency was significantly enhanced over that due to single equivalent total doses. These new data, in the low dose region, demonstrate an increased transformation frequency by fractionated versus single exposures of high-dose-rate fission-spectrum neutrons; an increase equal to that observed with low-dose-rate fission-spectrum neutrons. Estimates of the dose modifying factor (DMF), based upon the ratio of the initial linear portions of the induction curves for high-dose-rate neutrons and for low-dose-rate neutrons. However, when these results are compared to those following high-dose-rate /sup 60/Co ..gamma.. rays (100 rad/min), the relative biological effectiveness (RBE) for low-dose-rate fission-spectrum neutrons based upon slope ratios is 19.6; similarly, the RBE relative to five daily fractions of /sup 60/Co ..gamma.. rays is 78.8.
Research Organization:
Argonne National Lab., IL
DOE Contract Number:
W-31109-ENG-38
OSTI ID:
5517839
Journal Information:
Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 102:3; ISSN RAREA
Country of Publication:
United States
Language:
English

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Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BARYONS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
COBALT 60
COBALT ISOTOPES
CONNECTIVE TISSUE CELLS
DATA
DOSE RATES
ELECTROMAGNETIC RADIATION
ELEMENTARY PARTICLES
ENRICHED URANIUM REACTORS
EXPERIMENTAL DATA
FERMIONS
FIBROBLASTS
FISSION NEUTRONS
FRACTIONATED IRRADIATION
GAMMA RADIATION
HADRONS
INFORMATION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
JANUS REACTOR
LOW DOSE IRRADIATION
MAMMALS
MICE
MINUTES LIVING RADIOISOTOPES
NEUTRONS
NUCLEI
NUCLEONS
NUMERICAL DATA
ODD-ODD NUCLEI
ONCOGENIC TRANSFORMATIONS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOISOTOPES
RBE
REACTORS
RESEARCH AND TEST REACTORS
RESEARCH REACTORS
RODENTS
SOMATIC CELLS
TANK TYPE REACTORS
THERMAL REACTORS
VERTEBRATES
WATER COOLED REACTORS
WATER MODERATED REACTORS
YEARS LIVING RADIOISOTOPES