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Dependence of radiation-induced neoplastic transformation in vitro upon radiation quality and repair

Journal Article · · Natl. Bur. Stand. (U.S.), Spec. Publ.; (United States)
OSTI ID:6839312
;
C3H/10Tl/2 mouse embryo cells grown in culture were irradiated with single or fractionated doses of fission-spectrum neutrons from the JANUS reactor or with 50-kV x-rays; survival and frequencies of neoplastic transformation were measured and the relative biological effectiveness (RBE) for each end point was estimated. As expected, for both survival and transformation, RBE's depend upon level of effect, being higher for small than for large doses. Changes in transformation frequencies following x-ray dose fractionation indicate appreciable repair of both sublethal and subtransformation damage. Results of fractionation of the fission-spectrum neutron dose suggest repair of the first-dose subtransformation damage and no repair of sublethal damage. The observed results for the induction of neoplastic transformation in C3H/10Tl/2 cells are qualitatively similar to data for tumor induction in animals.
Research Organization:
Argonne National Lab.,IL
OSTI ID:
6839312
Journal Information:
Natl. Bur. Stand. (U.S.), Spec. Publ.; (United States), Journal Name: Natl. Bur. Stand. (U.S.), Spec. Publ.; (United States) Vol. 554; ISSN XNBSA
Country of Publication:
United States
Language:
English

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Related Subjects

550300 -- Cytology
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BARYONS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CARCINOGENESIS
CELL CULTURES
CELL KILLING
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
ELEMENTARY PARTICLES
EMBRYONIC CELLS
ENRICHED URANIUM REACTORS
FAST NEUTRONS
FERMIONS
FRACTIONATED IRRADIATION
HADRONS
IONIZING RADIATIONS
IRRADIATION
JANUS REACTOR
MAMMALS
MICE
NEUTRONS
NUCLEONS
PATHOGENESIS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RBE
REACTORS
RECOVERY
REPAIR
RESEARCH AND TEST REACTORS
RESEARCH REACTORS
RODENTS
TANK TYPE REACTORS
THERMAL REACTORS
VERTEBRATES
WATER COOLED REACTORS
WATER MODERATED REACTORS
X RADIATION