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Effect of radiation quality and repair processes on the incidence of neoplastic transformation in vitro. [X radiation, mice]

Conference ·
OSTI ID:6187895
;

Studies of the effect of radiation dose fractionation on survival of mammalian cells show that x-ray dose fractionation results in a substantial increase in net survival due to the rapid repair of sublethal damage. For high LET radiations, however, the magnitude of any net survival increase is appreciably less and may be essentially absent. Thus the capacity of cells to repair sublethal damage is an important factor in considering the effect of fractionation radiation exposure in the potential of surviving cells to produce cancer. The carcinogenic potential of dose fractionation has been studied in animals and in recent years it has been extensively studied in vitro. Using mouse embryo derived C3H/10T1/2 cells we have demonstrated that x-ray dose fractionation results in appreciable repair of cumulative damage related to transformation, i.e., subtransformation damage. Considerably less reduction in neoplastic transformation is observed after fission-spectrum neutron dose fractionation. This paper presents new information demonstrating that reduction in neoplastic transformation following dose fractionation is a result of repair of subtransformation damage, rather than repair of sublethal damage.

Research Organization:
Argonne National Lab., IL (USA)
Sponsoring Organization:
USDOE (United States)
DOE Contract Number:
W-31109-ENG-38
OSTI ID:
6187895
Report Number(s):
CONF-790524--9
Country of Publication:
United States
Language:
English

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Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BARYONS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CARCINOGENESIS
DATA
DATA FORMS
DISEASES
ELECTROMAGNETIC RADIATION
ELEMENTARY PARTICLES
EMBRYONIC CELLS
EMBRYOS
ENERGY TRANSFER
EXPERIMENTAL DATA
FERMIONS
FRACTIONATED IRRADIATION
GRAPHS
HADRONS
INFORMATION
INJURIES
IONIZING RADIATIONS
IRRADIATION
LET
MAMMALS
MICE
NEOPLASMS
NEUTRONS
NUCLEONS
NUMERICAL DATA
PATHOGENESIS
RADIATION EFFECTS
RADIATION INJURIES
RADIATION QUALITY
RADIATIONS
RADIOINDUCTION
RECOVERY
REPAIR
RODENTS
SURVIVAL TIME
VERTEBRATES
X RADIATION