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Neoplastic transformation and dose fractionation: does repair of damage play a role

Conference · · Radiat. Res.; (United States)
OSTI ID:5707113
;
The induction of neoplastically transformed cells has been measured with single and fractionated doses of 50-kV X rays and fission-spectrum neutrons from the Janus reactor at the Argonne National Laboratory. Combining these results with parallel measurements of cell survival permits an analysis of the possible roles of repair processes in the expression of sublethal and subtransformation damage. It is concluded that subtransformation damage due to X rays is repaired although probably more slowly than sublethal x-ray damage. Much less, if any, repair occurs between neutron doses for periods up to 24 h.
Research Organization:
Argonne National Lab., IL
DOE Contract Number:
W-31109-ENG-38
OSTI ID:
5707113
Conference Information:
Journal Name: Radiat. Res.; (United States) Journal Volume: 79:2
Country of Publication:
United States
Language:
English

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Related Subjects

550300* -- Cytology
560121 -- Radiation Effects on Cells-- External Source-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANL
BARYONS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CELL CULTURES
DOSES
ELECTROMAGNETIC RADIATION
ELEMENTARY PARTICLES
ENRICHED URANIUM REACTORS
FERMIONS
FISSION SPECTRA
FRACTIONATED IRRADIATION
HADRONS
IN VITRO
IONIZING RADIATIONS
IRRADIATION
JANUS REACTOR
NATIONAL ORGANIZATIONS
NEUTRONS
NUCLEONS
ONCOGENIC TRANSFORMATIONS
RADIATION DOSES
RADIATIONS
REACTORS
RECOVERY
REPAIR
RESEARCH AND TEST REACTORS
RESEARCH REACTORS
SUBLETHAL IRRADIATION
TANK TYPE REACTORS
THERMAL REACTORS
US AEC
US DOE
US ERDA
US ORGANIZATIONS
WATER COOLED REACTORS
WATER MODERATED REACTORS
X RADIATION