Transformation of mouse C3H/10T1/2 cells by single and fractionated doses of x-rays and fission-spectrum neutrons
Journal Article
·
· Cancer Res.; (United States)
OSTI ID:6739957
A mouse embryo-derived cell line, C3H/10T1/2, was used to measure the frequency of in vitro neoplastic transformation induced by 50-kVp x-rays and by fission-spectrum neutrons from the JANUS reactor at the Argonne National Laboratory. The transformation frequency after single x-ray doses rises exponentially, reaching a plateau at about 3 x 10(-3) transformant/survivor. The induction curve following single neutron doses, while qualitatively similar, initially rises more steeply and levels off at a maximum of about 6 x 10(-3) transformant/survivor. For both radiations, transformation frequency varies with changes in the number of viable cells per dish. Fractionation of a total x-ray dose of 700 rads results in an approximately 6-fold increase in survival and reduction in transformation frequency over a 16-hr interval. Fractionation of the total neutron dose of 378 rads has no effect upon cell survival, and transformation frequency declines by a factor of only about 1.7 at most over a 24-hr period.
- Research Organization:
- Argonne National Lab., IL
- OSTI ID:
- 6739957
- Journal Information:
- Cancer Res.; (United States), Journal Name: Cancer Res.; (United States) Vol. 39:1; ISSN CNREA
- Country of Publication:
- United States
- Language:
- English
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Transformation of mouse C3H/10T 1/2 cells by single and fractionated doses of x rays and fission-spectrum neutrons
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OSTI ID:7098298
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Sat Jun 01 00:00:00 EDT 1991
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Journal Article
·
Thu Mar 31 23:00:00 EST 1994
· Radiation Research
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OSTI ID:56761
Related Subjects
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACUTE EXPOSURE
ACUTE IRRADIATION
ANIMAL CELLS
ANIMALS
BARYONS
COMPARATIVE EVALUATIONS
DISEASES
ELECTROMAGNETIC RADIATION
ELEMENTARY PARTICLES
EMBRYONIC CELLS
ENRICHED URANIUM REACTORS
FERMIONS
FIBROSARCOMAS
FISSION NEUTRONS
FRACTIONATED IRRADIATION
HADRONS
IONIZING RADIATIONS
IRRADIATION
JANUS REACTOR
MAMMALS
MICE
NEOPLASMS
NEUTRONS
NUCLEONS
ONCOGENIC TRANSFORMATIONS
RADIATIONS
RADIOINDUCTION
RBE
REACTORS
RESEARCH AND TEST REACTORS
RESEARCH REACTORS
RODENTS
SARCOMAS
SOFT X RADIATION
SURVIVAL CURVES
TANK TYPE REACTORS
THERMAL REACTORS
VERTEBRATES
WATER COOLED REACTORS
WATER MODERATED REACTORS
X RADIATION
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACUTE EXPOSURE
ACUTE IRRADIATION
ANIMAL CELLS
ANIMALS
BARYONS
COMPARATIVE EVALUATIONS
DISEASES
ELECTROMAGNETIC RADIATION
ELEMENTARY PARTICLES
EMBRYONIC CELLS
ENRICHED URANIUM REACTORS
FERMIONS
FIBROSARCOMAS
FISSION NEUTRONS
FRACTIONATED IRRADIATION
HADRONS
IONIZING RADIATIONS
IRRADIATION
JANUS REACTOR
MAMMALS
MICE
NEOPLASMS
NEUTRONS
NUCLEONS
ONCOGENIC TRANSFORMATIONS
RADIATIONS
RADIOINDUCTION
RBE
REACTORS
RESEARCH AND TEST REACTORS
RESEARCH REACTORS
RODENTS
SARCOMAS
SOFT X RADIATION
SURVIVAL CURVES
TANK TYPE REACTORS
THERMAL REACTORS
VERTEBRATES
WATER COOLED REACTORS
WATER MODERATED REACTORS
X RADIATION