Malignant transformation of mouse C3H/10T 1/2 cells in vitro by x rays, fission-spectrum and d(80) + (Be + Ta)neutrons
Thesis/Dissertation
·
OSTI ID:5448791
Lethality and malignant transformation of mammalian cells exposed to neutrons and X rays were measured. Dose-response curves were obtained at doses relevant to raidation therapy, ranging from 0.5 to 12 Gy (1Gy = 100 rads). Cultured mouse embryo cells (C3H/10T 1/2) were used as a model system. Response of C3H/10T 1/2 cells to 100 kVp x rays TRIGA reactor fission neutrons and d(80) + (Be + Ta) cyclotron-produced neutrons were investigated. Results indicated that the number of transformants per survivor increased with increasing dose, and then leveled off at a dose that kills about 90% of the irradiated cells, regardless of the type of radiation used. The summary results were given in terms of the relative biological effectiveness (RBE) using 100 kVp as a reference radiation. The RBE values for cell killing as judged by survival curve slopes were 2.75 +- 0.2 for fission neutrons and 1.71 +- 0.1 for cyclotron neutrons and varied slightly at high survival levels. The RBE values for transformation ranged from 6 to 2.6 for fission neutrons when calculated at different transformation frequency levels. In the case of cyclotron-produced neutrons, the RBE for cell lethality was significantly higher than the RBE for cell transformation, which was 1 or less.
- Research Organization:
- Maryland Univ., College Park (USA)
- OSTI ID:
- 5448791
- Country of Publication:
- United States
- Language:
- English
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Transformation of mouse C3H/10T 1/2 cells by single and fractionated doses of x rays and fission-spectrum neutrons
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Transformation of mouse C3H/10T1/2 cells by single and fractionated doses of x-rays and fission-spectrum neutrons
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Sun Dec 31 23:00:00 EST 1978
· Cancer Res.; (United States)
·
OSTI ID:7098298
Absence of a dose-fractionation effect on neoplastic transformation induced by fission-spectrum neutrons in C3H 10T1/2 cells
Journal Article
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Sat Jun 01 00:00:00 EDT 1991
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Transformation of mouse C3H/10T1/2 cells by single and fractionated doses of x-rays and fission-spectrum neutrons
Journal Article
·
Sun Dec 31 23:00:00 EST 1978
· Cancer Res.; (United States)
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Related Subjects
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BARYONS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CELL KILLING
CONNECTIVE TISSUE CELLS
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
ELEMENTARY PARTICLES
EMBRYONIC CELLS
ENERGY TRANSFER
FAST NEUTRONS
FERMIONS
FIBROBLASTS
FISSION NEUTRONS
HADRONS
IN VITRO
IONIZING RADIATIONS
LET
MAMMALS
MICE
MORPHOLOGY
NEUTRONS
NUCLEONS
ONCOGENIC TRANSFORMATIONS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RBE
RODENTS
SOMATIC CELLS
VERTEBRATES
X RADIATION
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BARYONS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CELL KILLING
CONNECTIVE TISSUE CELLS
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
ELEMENTARY PARTICLES
EMBRYONIC CELLS
ENERGY TRANSFER
FAST NEUTRONS
FERMIONS
FIBROBLASTS
FISSION NEUTRONS
HADRONS
IN VITRO
IONIZING RADIATIONS
LET
MAMMALS
MICE
MORPHOLOGY
NEUTRONS
NUCLEONS
ONCOGENIC TRANSFORMATIONS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RBE
RODENTS
SOMATIC CELLS
VERTEBRATES
X RADIATION