Pulmonary tumorigenesis in Syrian golden hamsters after intratracheal instillations with automobile exhaust condensate
Syrian golden hamsters were intratracheally instilled once every two weeks for life with automobile exhaust condensate (AEC) at two dose levels. The condensate was prepared from the most common German passenger car driven in the Europa-Test cycle (simulated city driving) and contained 340 ..mu..g/g benzo(a)pyrene (B(a)P). Despite the very low total dose of B(a)P received, all animals of both dosage groups developed multiple pulmonary adenomas. Electron microscopy revealed these tumors to resemble B(a)P induced pulmonary adenomas in their ultrastructure. Numerous condensate-laden macrophages in tumor and peripheral lung tissues indicated that little of the instilled condensate had been removed from the airways through mucociliary action.
- Research Organization:
- Medizinische Hochschule, Hanover
- OSTI ID:
- 7098206
- Journal Information:
- Cancer; (United States), Journal Name: Cancer; (United States) Vol. 40:1; ISSN CANCA
- Country of Publication:
- United States
- Language:
- English
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AIR POLLUTION
ANIMAL CELLS
ANIMALS
AUTOMOBILES
BIOLOGICAL EFFECTS
BODY
CONNECTIVE TISSUE CELLS
DISEASES
ELECTRON MICROSCOPY
ENVIRONMENTAL EFFECTS
EXHAUST GASES
GASEOUS WASTES
HAMSTERS
INTRATRACHEAL ADMINISTRATION
LUNGS
MACROPHAGES
MAMMALS
MICROSCOPY
NEOPLASMS
ORGANS
PHAGOCYTES
POLLUTION
RESPIRATORY SYSTEM
RODENTS
SOMATIC CELLS
VEHICLES
VERTEBRATES
WASTES