Tumur induction by 7H-dibenzo(c,g)carbazole in the respiratory tract of Syrian hamsters

Journal Article · Wed Nov 30 23:00:00 EST 1977 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287397709529627· OSTI ID:6721844

Sellakumar, A ^[1]; Stenbaeck, F; Rowland, J; Shubik, P

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1. New York Univ., Tuxedo

The respiratory tract of male and female Syrian golden hamsters was treated intratracheally with 7H-dibenzol(c,g)carbazole (DBC), a tobacco smoke component. The carcinogen was given by multiple instillations at two dose levels. At the lower dose (9 mg), 35 of 46 hamsters (72 percent) developed respiratory tract tumors. The group receiving treatment at the higher dose level (30 mg) died earlier because of the toxicity of the compound. In this group, 15 of 45 animals (33 percent) had respiratory tract tumors. These occurred in the larynx, trachea, bronchi, and lungs, but predominated in the trachea and bronchi. Morphologically, most tumors were papillomas and squamous cell carcinomas. This study indicates the highly potent carcinogenic effect of DBC and that respiratory tumors can be induced in this model system without any carrier dust.

• OSTI ID: 6721844
• Journal Information: J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 3:5-6; ISSN JTEHD
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
ANIMALS
AZOLES
BIOLOGICAL EFFECTS
BIOLOGICAL MODELS
BRONCHI
CARBAZOLES
CARCINOGENESIS
CARCINOGENS
CARCINOMAS
COLLOIDS
DISEASES
DISPERSIONS
DOSE-RESPONSE RELATIONSHIPS
HAMSTERS
HETEROCYCLIC COMPOUNDS
INTRATRACHEAL ADMINISTRATION
MAMMALS
NEOPLASMS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PATHOGENESIS
RESIDUES
RESPIRATORY SYSTEM
RODENTS
SMOKES
SOLS
TOBACCO SMOKES
TRACHEA
VERTEBRATES