Glass fibers and vapor phase components of cigarette smoke as cofactors in experimental respiratory tract carcinogenesis
Syrian golden hamsters were given intratracheal instillations of glass fibers with or without BP suspended in saline, once a fortnight for 52 weeks; the experiment was terminated at week 85. No tumors of the respiratory tract were observed in hamsters treated with glass fibers alone. There was no indication that glass fibers enhanced the development of respiratory tract tumors induced by BP. In another study Syrian golden hamsters were exposed to fresh air or to a mixture of 4 major vapor phase components of cigarette smoke, viz. isoprene (800----700 ppm), methyl chloride (1000----900 ppm), methyl nitrite (200----190 ppm) and acetaldehyde (1400----1200 ppm) for a period of at most 23 months. Some of the animals were also given repeated intratracheal instillations of BP or norharman in saline. Laryngeal tumors were found in 7/31 male and 6/32 female hamsters exposed only to the vapor mixture, whereas no laryngeal tumors occurred in controls. The tumor response of the larynx most probably has to be ascribed entirely to the action of acetaldehyde. Simultaneous treatment with norharman or BP did not affect the tumor response of the larynx. Acetaldehyde may occur in the vapor phase of cigarette smoke at levels up to 2000 ppm. Chronic inhalation exposure of rats to acetaldehyde at levels of 0 (controls), 750, 1500 or 3000----1000 ppm resulted in a high incidence of nasal carcinomas, both squamous cell carcinomas of the respiratory epithelium and adenocarcinomas of the olfactory epithelium. It was discussed that acetaldehyde may significantly contribute to the induction of bronchogenic cancer by cigarette smoke in man.
- Research Organization:
- Institute CIVO, Zeist, Netherland
- OSTI ID:
- 5216256
- Journal Information:
- Carcinog. Compr. Surv.; (United States), Journal Name: Carcinog. Compr. Surv.; (United States)
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
GLASS
BIOLOGICAL EFFECTS
RESPIRATORY SYSTEM
NEOPLASMS
TOBACCO SMOKES
CARCINOGENESIS
ACETALDEHYDE
FIBERS
HAMSTERS
ISOPRENE
METHYL CHLORIDE
MIXTURES
RATS
SYNERGISM
VAPORS
AEROSOLS
ALDEHYDES
ANIMALS
CHLORINATED ALIPHATIC HYDROCARBONS
COLLOIDS
DIENES
DISEASES
DISPERSIONS
FLUIDS
GASES
HALOGENATED ALIPHATIC HYDROCARBONS
HYDROCARBONS
MAMMALS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
PATHOGENESIS
POLYENES
RESIDUES
RODENTS
SMOKES
SOLS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)