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Carcinomas of the respiratory tract in hamsters given arsenic trioxide and/or benzo(a)pyrene by the pulmonary route

Journal Article · · Environ. Res.; (United States)
; ;

The pulmonary carcinogenicity of arsenic trioxide (As) alone and in combination with benzo(a)pyrene (BP) was studied in male Syrian golden hamsters given 15 weekly intratracheal instillations. The animals were divided into four groups: As, BP, As + BP, and controls. At each instillation about 3 mg/kg body wt As arsenic and/or 6 mg/kg body wt of BP was administered. All groups received a carrier dust (charcoal carbon), which increased the lung retention of arsenic, as well as sulfuric acid. Carcinomas of the larynx, trachea, bronchi, or lungs were found in 3, 17, and 25 of 47, 40, and 54 animals examined in the As, BP, and As + BP groups. No respiratory tract carcinomas were found in 53 control animals. The incidence of pulmonary adenomas, papillomas, and adenomatoid lesions was markedly higher in the As group than in the control group. Taken together the data provide strong evidence that arsenic trioxide can induce lung carcinomas. Furthermore, there was some evidence of a positive interaction between arsenic and BP in relation to adenomatous lung tumors, which could be of importance for the synergism between arsenic and smoking observed in smelter workers.

Research Organization:
Karolinska Inst., Stockholm, Sweden
OSTI ID:
5927677
Journal Information:
Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 34:2; ISSN ENVRA
Country of Publication:
United States
Language:
English

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Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADENOMAS
ANIMALS
AROMATICS
ARSENIC COMPOUNDS
ARSENIC OXIDES
BENZOPYRENE
BIOLOGICAL EFFECTS
CARCINOMAS
CHALCOGENIDES
CONDENSED AROMATICS
DATA
DISEASE INCIDENCE
DISEASES
EXPERIMENTAL DATA
HAMSTERS
HYDROCARBONS
HYDROGEN COMPOUNDS
INFORMATION
INORGANIC ACIDS
INTRATRACHEAL ADMINISTRATION
MAMMALS
NEOPLASMS
NUMERICAL DATA
ORGANIC COMPOUNDS
OXIDES
OXYGEN COMPOUNDS
PATHOLOGICAL CHANGES
RESPIRATORY SYSTEM
RODENTS
SULFURIC ACID
VERTEBRATES