Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Deposition and localization of polonium-210 intratracheally instilled in the hamster lung as determined by autoradiography of freeze-dried sections

Journal Article · · Radiat. Res.; (United States)
DOI:https://doi.org/10.2307/3574665· OSTI ID:7259707
; ;

Freeze-dry autoradiography was used to study the deposition, localization, and clearance mechanisms of /sup 210/Po in the lungs of Syrian golden hamsters following single or multiple intratracheal instillations. This method of exposure to /sup 210/Po resulted in a relatively uniform dose of ..cap alpha.. radiation to the entire peripheral lung, including alveoli, respiratory, and terminal bronchioles. Relatively little radiation dose was delivered to the tracheal and bronchial epithelium. Most of the /sup 210/Po was originally deposited in the alveolar region; however, clearance, via the airways and bloodstream, began immediately after instillation. Single or multiple intratrachael instillations of /sup 210/Po in saline are appropriate methods of delivering a relatively uniform dose of ..cap alpha.. radiation to the bronchiolar--alveolar region of small experimental animals, particularly when compared to localized doses which result from the administration of /sup 210/Po on particles.

Research Organization:
Harvard School of Public Health, Boston
OSTI ID:
7259707
Journal Information:
Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 69:3; ISSN RAREA
Country of Publication:
United States
Language:
English

Similar Records

Quantitative scanning electron microscopic autoradiography of inhaled /sup 239/PuO/sub 2/
Journal Article · Tue Feb 28 23:00:00 EST 1989 · Health Phys.; (United States) · OSTI ID:6072211
Effect of dose rate on the induction of experimental lung cancer in hamsters by. cap alpha. radiation
Journal Article · Thu Aug 01 00:00:00 EDT 1985 · Radiat. Res.; (United States) · OSTI ID:5264910
Serial sacrifice study of pathogenesis of /sup 210/Po-induced lung tumors in Syrian golden hamsters
Journal Article · Fri Mar 31 23:00:00 EST 1978 · Cancer Res.; (United States) · OSTI ID:5759632

Related Subjects

560172* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALPHA DECAY RADIOISOTOPES
ANIMALS
AUTORADIOGRAPHY
BIOLOGICAL LOCALIZATION
BODY
DAYS LIVING RADIOISOTOPES
DEPOSITION
DOSES
EVEN-EVEN NUCLEI
HAMSTERS
HEAVY NUCLEI
INTRATRACHEAL ADMINISTRATION
ISOTOPES
LUNGS
MAMMALS
NUCLEI
ORGANS
POLONIUM 210
POLONIUM ISOTOPES
RADIATION DOSES
RADIOISOTOPES
RADIONUCLIDE KINETICS
RESPIRATORY SYSTEM
RODENTS
VERTEBRATES