Serial sacrifice study of pathogenesis of /sup 210/Po-induced lung tumors in Syrian golden hamsters
Journal Article
·
· Cancer Res.; (United States)
OSTI ID:5759632
The pathogenesis of /sup 210/Po-induced tumors in the peripheral lung of Syrian golden hamsters has been studied in a serial sacrifice experiment utilizing both plastic (glycol methacrylate) and routine paraffin embedding procedures for lung sections. A rapid progression from hyperplasia of bronchiolar-type cells that appear in the alveolar region to malignant tumors was documented. Tumors began appearing as early as 15 weeks after the first intratracheal instillation of /sup 210/Po.
- Research Organization:
- Harvard Univ., Boston, MA
- OSTI ID:
- 5759632
- Journal Information:
- Cancer Res.; (United States), Journal Name: Cancer Res.; (United States) Vol. 38:4; ISSN CNREA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550604 -- Medicine-- Unsealed Radionuclides in Therapy-- (1980-)
550901 -- Pathology-- Tracer Techniques
560172* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALPHA DECAY RADIOISOTOPES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARCINOGENESIS
DAYS LIVING RADIOISOTOPES
DISEASES
EVEN-EVEN NUCLEI
HAMSTERS
HEAVY NUCLEI
INTRATRACHEAL ADMINISTRATION
ISOTOPES
LUNGS
MAMMALS
NEOPLASMS
NUCLEI
ORGANS
PATHOGENESIS
PATHOLOGICAL CHANGES
POLONIUM 210
POLONIUM ISOTOPES
RADIATION EFFECTS
RADIOINDUCTION
RADIOISOTOPES
RESPIRATORY SYSTEM
RODENTS
TOXICITY
VERTEBRATES
550901 -- Pathology-- Tracer Techniques
560172* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALPHA DECAY RADIOISOTOPES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARCINOGENESIS
DAYS LIVING RADIOISOTOPES
DISEASES
EVEN-EVEN NUCLEI
HAMSTERS
HEAVY NUCLEI
INTRATRACHEAL ADMINISTRATION
ISOTOPES
LUNGS
MAMMALS
NEOPLASMS
NUCLEI
ORGANS
PATHOGENESIS
PATHOLOGICAL CHANGES
POLONIUM 210
POLONIUM ISOTOPES
RADIATION EFFECTS
RADIOINDUCTION
RADIOISOTOPES
RESPIRATORY SYSTEM
RODENTS
TOXICITY
VERTEBRATES