Potentiating effect of methyl methane sulfonate on friend virus leukemogenesis in vivo (40522)

Journal Article · Sun Dec 31 23:00:00 EST 1978 · Proc. Soc. Exp. Biol. Med.; (United States)

DOI:https://doi.org/10.3181/00379727-161-40522· OSTI ID:7097014

Raikow, R B; Meredith, R F; Brozovich, B J; Seeman, P R; Livingston, A E; Okunewick, J P

Methyl methane sulfonate (MMS) given ip five hours before Friend Leukemia Virus (FLV) injection enhanced the leukemogenic action of FLV in virus-sensitive SJL/J mice and also in relatively virus-resistant B10SJF/sub 1/ mice. MMS also decreased the humoral immune response, as measured by plaque forming cell assay. However, the timing of the effect of MMS on the immune system did not coincide with the timing of the MMS related potentiation of leukemia. Hence, it is suggested that the potentiating effect of this chemical on viral leukemogenesis is more likely due to events occurring at the intracellular level than at the level of humoral immune response.

• Research Organization: Allegheny General Hospital, Pittsburgh, PA
• OSTI ID: 7097014
• Journal Information: Proc. Soc. Exp. Biol. Med.; (United States), Journal Name: Proc. Soc. Exp. Biol. Med.; (United States) Vol. 161; ISSN PSEBA
• Country of Publication: United States
• Language: English

Related Subjects

550700 -- Microbiology
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTIGEN-ANTIBODY REACTIONS
BIOLOGICAL EFFECTS
ESTERS
IMMUNOSUPPRESSION
IN VIVO
INJECTION
INTAKE
INTRAPERITONEAL INJECTION
LEUKEMIA VIRUSES
MAMMALS
METHYL METHANESULFONATE
MICE
MICROORGANISMS
MUTAGENS
ONCOGENIC VIRUSES
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
PARASITES
PLAQUE FORMATION
RODENTS
SIDE EFFECTS
SULFONIC ACID ESTERS
SYNERGISM
VERTEBRATES
VIRUSES