Leukemia induction in SJL/J mice treated with methyl methane sulfonate and Friend virus

Technical Report · Thu Jun 01 04:00:00 EDT 1978

DOI:https://doi.org/10.2172/6586773· OSTI ID:6586773

Raikow, R B; OKunewick, J P; Meredith, R F; Brozovich, B J; Seeman, P R

Methyl methane sulfonate (MMS) given to SJL/J mice in conjunction with Friend leukemia virus (FLV) enhanced leukemogenesis. The time of MMS administration in relation to FLV inoculation was varied. MMS was effective in leukemogenic enhancement only if given within 24 hrs preceding the virus. MMS given 5 hrs after the virus was slightly protective. MMS was also found to have an immunosuppressive effect as measured by a depressed plaque forming response to sheep red blood cells. However, the nadir of this response did not correspond to the peak of leukemia virus enhancement.

• Research Organization: Allegheny-Singer Research Corp., Pittsburgh, PA (USA)
• OSTI ID: 6586773
• Report Number(s): COO-4800-3
• Country of Publication: United States
• Language: English

Related Subjects

550900* -- Pathology
560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
CARCINOGENESIS
DOMESTIC ANIMALS
ESTERS
IMMUNOSUPPRESSION
KINETICS
LEUKEMIA VIRUS
LEUKEMOGENESIS
MAMMALS
METHYL METHANESULFONATE
MICE
MUTAGENS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
PATHOGENESIS
REACTION KINETICS
RODENTS
RUMINANTS
SHEEP
SULFONIC ACID ESTERS
VERTEBRATES