Leukemia induction by Friend virus in normally leukemia virus resistant mice after treatment with methyl methane sulfonate

Technical Report · Fri Mar 31 23:00:00 EST 1978

DOI:https://doi.org/10.2172/6572769· OSTI ID:6572769

Raikow, R B; OKunewick, J P; Meredith, R F; Brozovich, B J; Seeman, P R

F1 offspring of virus-resistant C57B1/10 females and virus-sensitive SJL/J males are normally resistant to Friend leukemia virus. However, after treatment of these hybrids with methyl methane sulfonate (MMS), Friend leukemia virus given within 5 hrs of the treatment caused many individuals to succumb to erythroleukemia with characteristic elevated white counts, hepatometaly, splenomegaly, and high hematocrit. Although MMS was found immunosuppressive in these mice when given alone, it was found to enhance humoral immune function measured by a plaque forming assay against sheep red blood cells, when given in combination with the virus. These results suggest that MMS enhances viral leukemogenesis by some mechanism other than immunosuppression.

• Research Organization: Allegheny-Singer Research Corp., Pittsburgh, PA (USA)
• OSTI ID: 6572769
• Report Number(s): COO-4800-1
• Country of Publication: United States
• Language: English

Related Subjects

550900* -- Pathology
560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CARCINOGENESIS
DISEASES
ERYTHROCYTES
ESTERS
IMMUNOSUPPRESSION
KINETICS
LEUKEMIA VIRUS
LEUKEMOGENESIS
MAMMALS
METHYL METHANESULFONATE
MICE
MUTAGENS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
PATHOGENESIS
PATHOLOGICAL CHANGES
REACTION KINETICS
RODENTS
SULFONIC ACID ESTERS
VERTEBRATES