Stimulation of immune response in hybrid mice following Rauscher virus infection
Journal Article
·
· Proc. Soc. Exp. Biol. Med.; (United States)
The effect of Rauscher leukemia virus injection on the splenic plaque former cells (PFC) response to sheep red blood cells (SRBC) was measured in a mouse strain sensitive to the virus (SJL/J), one resistant to the virus (C57B1/10), and their F/sub 1/ hybrid (SJL/JxC57B1/10)F/sub 1/. In contrast to previous findings of a suppressive effect of Friend virus on PFC response in another hybrid of different resistant and sensitive strains, a significant immunostimulation was seen. Immunostimulation was also seen in the resistant parent when the PFC response level was measured 12 days or later after RLV infection, while the PFC response of the sensitive parent was nearly completely suppressed. Evaluation of the effect of RLV on the splenic masses of the three strains indicated a mild transient splenomegaly in the hybrid; a pronounced splenomegaly in the sensitive parent; and no effect on the resistant strain. Comparison of the data suggests that the change in splenic PFC number in the hybrid following RLV infection occurs as a function partially independent of changes in the total splenic mass.
- Research Organization:
- Allegheny General Hospital, Pittsburgh
- OSTI ID:
- 6724166
- Journal Information:
- Proc. Soc. Exp. Biol. Med.; (United States), Journal Name: Proc. Soc. Exp. Biol. Med.; (United States) Vol. 157; ISSN PSEBA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Leukemia induction by Friend virus in normally leukemia virus resistant mice after treatment with methyl methane sulfonate
Regulation of immune responses in SJL and F1 hybrid mice by gamma-irradiated syngeneic lymphoma cells
Growth rate and /sup 59/Fe uptake in the progeny of Rauscher leukemia virus-infected splenic colony forming units following transplantation
Technical Report
·
Fri Mar 31 23:00:00 EST 1978
·
OSTI ID:6572769
Regulation of immune responses in SJL and F1 hybrid mice by gamma-irradiated syngeneic lymphoma cells
Journal Article
·
Sat Dec 31 23:00:00 EST 1983
· J. Natl. Cancer Inst.; (United States)
·
OSTI ID:7013574
Growth rate and /sup 59/Fe uptake in the progeny of Rauscher leukemia virus-infected splenic colony forming units following transplantation
Journal Article
·
Sat Mar 31 23:00:00 EST 1973
· J. Lab. Clin. Med.; (United States)
·
OSTI ID:7126151
Related Subjects
550700 -- Microbiology
550900* -- Pathology
551000 -- Physiological Systems
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
ANIMALS
ANTIBODIES
BIOASSAY
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
DOMESTIC ANIMALS
ERYTHROCYTES
HYBRIDIZATION
IMMUNE REACTIONS
IMMUNOLOGY
MAMMALS
MICE
MICROORGANISMS
ONCOGENIC VIRUSES
ORGANS
PARASITES
RODENTS
RUMINANTS
SHEEP
SIZE
SOMATIC CELLS
SPLEEN
SPLEEN CELLS
STIMULATION
VERTEBRATES
VIRUSES
550900* -- Pathology
551000 -- Physiological Systems
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
ANIMALS
ANTIBODIES
BIOASSAY
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
DOMESTIC ANIMALS
ERYTHROCYTES
HYBRIDIZATION
IMMUNE REACTIONS
IMMUNOLOGY
MAMMALS
MICE
MICROORGANISMS
ONCOGENIC VIRUSES
ORGANS
PARASITES
RODENTS
RUMINANTS
SHEEP
SIZE
SOMATIC CELLS
SPLEEN
SPLEEN CELLS
STIMULATION
VERTEBRATES
VIRUSES