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Suppression of thyroid radioiodine uptake by various doses of stable iodide

Journal Article · · New Engl. J. Med.; (United States)
; ; ; ; ;

We studied the effect of various doses of sodium iodide on thyroid radioiodine uptake in euthyroid volunteers by giving single doses of 10, 30, 50, and 100 mg and then daily doses of 10, 15, 30, 50, or 100 mg for 12 days thereafter. All single doses above 10 mg suppressed 24h thyroid uptake of /sup 123/I to 0.7 to 1.5 per cent. Continued daily administration of 15 mg of iodide or more resulted in values consistently below 2 per cent. A small but statistically significant fall in serum thyroxine (T/sub 4/) and triiodothyronine (T/sub 3/) and a rise in serum thyrotropin (TSH) concentrations were observed after eight and 12 days of iodide treatment. This study provides guidelines for stable iodide prophylaxis in the event of exposure to radioactive iodine.

Research Organization:
Univ. of Massachusetts, Worcester
OSTI ID:
7096869
Journal Information:
New Engl. J. Med.; (United States), Journal Name: New Engl. J. Med.; (United States) Vol. 303:19; ISSN NEJMA
Country of Publication:
United States
Language:
English

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Related Subjects

560171* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METAL COMPOUNDS
AMINO ACIDS
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL ACCUMULATION
BODY
CARBOXYLIC ACIDS
DOSE-RESPONSE RELATIONSHIPS
ELECTRON CAPTURE RADIOISOTOPES
ENDOCRINE GLANDS
GLANDS
HALIDES
HALOGEN COMPOUNDS
HORMONES
HOURS LIVING RADIOISOTOPES
INORGANIC PHOSPHORS
INTERMEDIATE MASS NUCLEI
IODIDES
IODINE 123
IODINE COMPOUNDS
IODINE ISOTOPES
ISOTOPES
MAMMALS
MAN
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC IODINE COMPOUNDS
ORGANS
PEPTIDE HORMONES
PHOSPHORS
PITUITARY HORMONES
PRIMATES
RADIOISOTOPES
RADIONUCLIDE KINETICS
SODIUM COMPOUNDS
SODIUM IODIDES
THYROID
THYROID HORMONES
THYROXINE
TIME DEPENDENCE
TRIIODOTHYRONINE
TSH
VERTEBRATES