Six-day study of the effect of 100 $mu$g triiodothyronine/day on the early thyroidal uptake of radioiodine in euthyroid and hyperthyroid subjects
The effect of the oral administration of 100 mu g of triiodothyronine (T/sub 3/) daily for six consecutive days on the early (10-min) radioiodine uptake by the thyroid gland was studied in 48 euthyroid subjects and 16 patients with hyperthyroidism by daily measurements of the 10-min /sup 132/I uptake. The changes of the /sup 132/I uptake of the euthyroid subjects during T/sub 3/ administration could be described by the equation: Y = 78e sup(-0.0995t) - 22e sup(-1.155t), where Y = /sup 132/I uptake in per cent of the control value and t: time in days. No significant changes of the /sup 132/I uptake values of the hyperthyroid subjects were Observed. Forty eight hours after the first T/sub 3/ dose the /sup 132/I uptake values of the euthyroid subjects were lower than those of the hyperthyroid ones in all instances but one. It is suggested that measurements of the early (10-min) /sup 132/I uptake 48 or 72 hours after starting T/sub 3/ administration provide a very useful and practical criterion for evaluating the results of the T/sub 3/ thyroid suppression test, especially since in comparison to the classical one the duration of the test can be shortened to 2 to 3 days, the radiation dose delivered to the gland is radically reduced and the discrimination between suppressors and non-suppressors was found to be far better with the proposed modification than with the classical test. (GE)
- Research Organization:
- Evangelismos Hospital, Athens
- NSA Number:
- NSA-29-018660
- OSTI ID:
- 4344374
- Journal Information:
- Nucl.-Med., v. 12, no. 3, pp. 189-201, Journal Name: Nucl.-Med., v. 12, no. 3, pp. 189-201; ISSN NMIMA
- Country of Publication:
- Germany
- Language:
- English
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