Effect of chronic douching with polyvinylpyrrolidone-iodine on iodine absorption and thyroid function
Journal Article
·
· Obstet. Gynecol.; (United States)
OSTI ID:6719150
Daily vaginal douching with polyvinylpyrrolidone-iodine in 12 euthyroid volunteers for 14 days resulted in a significant increase in serum total iodine concentration and urine iodine excretion. The increase in serum total iodine was associated with a marked decrease in 24-hour /sup 123/I uptake by the thyroid and a small but significant increase in serum thyrotropin (TSH) concentration. However, values for serum TSH never rose above the normal range. No significant changes in serum thyroxine (T4), free T4 index (FTI), or triiodothyronine concentrations were observed, although serum T4 and FTI did decrease slightly during treatment. The findings suggest that iodine is absorbed across the vaginal mucosa and that the subsequent increase in serum total iodine does induce subtle increases in serum TSH concentration. There was no evidence, however, of overt hypothyroidism in these euthyroid women.
- Research Organization:
- Division of Endocrinology and Metabolism, University of Massachusetts Medical School, Worcester
- OSTI ID:
- 6719150
- Journal Information:
- Obstet. Gynecol.; (United States), Journal Name: Obstet. Gynecol.; (United States) Vol. 60:1; ISSN OBGNA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550201* -- Biochemistry-- Tracer Techniques
551001 -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
BETA DECAY RADIOISOTOPES
BLOOD SERUM
BODY
DIAGNOSIS
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
ENDOCRINE DISEASES
ENDOCRINE GLANDS
FEMALE GENITALS
FEMALES
GLANDS
GYNECOLOGY
HALOGENS
HORMONES
HOURS LIVING RADIOISOTOPES
HYPOTHYROIDISM
INTERMEDIATE MASS NUCLEI
IODINE
IODINE 123
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MAN
MEDICINE
METABOLISM
NONMETALS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PEPTIDE HORMONES
PHYSIOLOGY
PITUITARY HORMONES
PRIMATES
RADIOISOTOPES
RADIONUCLIDE KINETICS
THYROID
TSH
VERTEBRATES
WOMEN
551001 -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
BETA DECAY RADIOISOTOPES
BLOOD SERUM
BODY
DIAGNOSIS
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
ENDOCRINE DISEASES
ENDOCRINE GLANDS
FEMALE GENITALS
FEMALES
GLANDS
GYNECOLOGY
HALOGENS
HORMONES
HOURS LIVING RADIOISOTOPES
HYPOTHYROIDISM
INTERMEDIATE MASS NUCLEI
IODINE
IODINE 123
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MAN
MEDICINE
METABOLISM
NONMETALS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PEPTIDE HORMONES
PHYSIOLOGY
PITUITARY HORMONES
PRIMATES
RADIOISOTOPES
RADIONUCLIDE KINETICS
THYROID
TSH
VERTEBRATES
WOMEN