Metabolites of benzo(a) pyrene produced by placental microsomes from cigarette smokers and nonsmokers

Journal Article · Fri Apr 01 04:00:00 EST 1977 · Life Sci.; (United States)

DOI:https://doi.org/10.1016/0024-3205(77)90501-X· OSTI ID:7094379

Wang, I Y ^[1]; Rasmussen, R E; Creasey, R; Crocker, T T

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1. Medical Univ. of South Carolina, Charleston

Placental microsomes from a large majority of nonsmokers in this study showed almost undetectable specific activity in metabolizing benzo(a)pyrene (BaP) in vitro. The microsomal fraction of the placentas from individuals who smoked cigarettes during pregnancy had the highest activity in metabolizing BaP than other subcellular fractions. Cigarette smoking during pregnancy induced placental enzymes which converted BaP to a variety of metabolites: the yield of 3-hydroxy-BaP (3-OH-BaP) and other phenols of BaP was the largest among the BaP metabolites, 7,8-dihydrodihydroxy-BaP (7,8-diol) having 13-72% the yield of 3-OH-BaP. Other metabolites included 9,10-dihydrodihydroxy-BaP (9,10-diol), 4,5-dihydrodihydroxy-BaP (4,5-diol), quinones of BaP and unidentified metabolites which were more polar than the diols.

• OSTI ID: 7094379
• Journal Information: Life Sci.; (United States), Journal Name: Life Sci.; (United States) Vol. 20:7; ISSN LIFSA
• Country of Publication: United States
• Language: English

Related Subjects

550200 -- Biochemistry
550500* -- Metabolism
59 BASIC BIOLOGICAL SCIENCES
AEROSOLS
ALCOHOLS
ANIMALS
AROMATICS
BENZOPYRENE
BIOLOGICAL EFFECTS
CELL CONSTITUENTS
COLLOIDS
CONDENSED AROMATICS
DISPERSIONS
FEMALES
FETAL MEMBRANES
GLYCOLS
HYDROCARBONS
HYDROXY COMPOUNDS
IN VITRO
MAMMALS
MAN
MEMBRANES
METABOLISM
MICROSOMES
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANOIDS
PHENOLS
PLACENTA
PREGNANCY
PRIMATES
QUINONES
RESIDUES
SMOKES
SOLS
TOBACCO SMOKES
VERTEBRATES
WOMEN