Metabolism of benzo(a)pyrene by human lung microsomal fractions
Journal Article
·
· Life Sci.; (United States)
The metabolism of benzo(a)pyrene was studied using microsomal fractions obtained from human lung derived at either resection or autopsy. The rates of metabolism and metabolite distribution were monitored using high pressure liquid chromatography and the metabolic rates were noted to be similar to those obtained using rat lung microsomes. In contrast to the rat, human lung microsomes appear to form a higher percentage of the 7,8-dihydro-7,8-diol or 9,10-dihydro-9,10-diol of benzo(a)pyrene as a fraction of the total metabolites. However, there was a significant variation among the human lung microsomal preparations which might reflect the clinical diagnosis and/or individual variation.
- Research Organization:
- Univ. of Texas Health Science Center, Dallas
- OSTI ID:
- 5087255
- Journal Information:
- Life Sci.; (United States), Journal Name: Life Sci.; (United States) Vol. 21:11; ISSN LIFSA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550200 -- Biochemistry
550500 -- Metabolism
560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALCOHOLS
ANIMALS
AROMATICS
AUTOPSY
BENZOPYRENE
BODY
CELL CONSTITUENTS
CHROMATOGRAPHY
CONDENSED AROMATICS
DIAGNOSTIC TECHNIQUES
GLYCOLS
HYDROCARBONS
HYDROXY COMPOUNDS
LUNGS
MAMMALS
MAN
METABOLISM
MICROSOMES
ORGANIC COMPOUNDS
ORGANOIDS
ORGANS
PRIMATES
RATS
RESPIRATORY SYSTEM
RODENTS
SEPARATION PROCESSES
VERTEBRATES
550500 -- Metabolism
560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALCOHOLS
ANIMALS
AROMATICS
AUTOPSY
BENZOPYRENE
BODY
CELL CONSTITUENTS
CHROMATOGRAPHY
CONDENSED AROMATICS
DIAGNOSTIC TECHNIQUES
GLYCOLS
HYDROCARBONS
HYDROXY COMPOUNDS
LUNGS
MAMMALS
MAN
METABOLISM
MICROSOMES
ORGANIC COMPOUNDS
ORGANOIDS
ORGANS
PRIMATES
RATS
RESPIRATORY SYSTEM
RODENTS
SEPARATION PROCESSES
VERTEBRATES