Comparative metabolism of benzo[a]pyrene by liver microsomes of channel catfish and brown bullhead

Journal Article · Tue Apr 01 04:00:00 EST 1997 · Environmental Toxicology and Chemistry

DOI:https://doi.org/10.1897/1551-5028(1997)016<0835:CMOBAP>2.3.CO;2· OSTI ID:514527

Yuan, Z X; Kumar, S; Sikka, H C ^[1]

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1. State Univ. of New York Coll., Buffalo, NY (United States). Environmental Toxicology and Chemistry Lab.

The authors investigated the metabolism of the carcinogen benzo[a]pyrene (BaP) by liver microsomes of channel catfish (Ictalurus punctatus) and brown bullhead (Ameiurus nebulosus) pretreated with 3-methylcholanthrene. The catfish liver microsomes metabolized BaP at a considerably lower rate than did the brown bullhead liver microsomes. Although the BaP metabolites produced by the liver microsomes of the two species were qualitatively similar, there were considerable differences in the relative proportions of individual metabolites formed. The catfish liver microsomes produced a considerably lower proportion of benzo-ring diols of BaP including BaP-7,8-diol (the proximate carcinogenic metabolite of BaP) than did the bullhead liver microsomes. Compared to the bullhead liver microsomes, the catfish microsomes converted a higher proportion of BaP to phenolic metabolites.

• Sponsoring Organization: USDOE
• OSTI ID: 514527
• Journal Information: Environmental Toxicology and Chemistry, Journal Name: Environmental Toxicology and Chemistry Journal Issue: 4 Vol. 16; ISSN 0730-7268; ISSN ETOCDK
• Country of Publication: United States
• Language: English

Related Subjects

54 ENVIRONMENTAL SCIENCES
56 BIOLOGY AND MEDICINE
APPLIED STUDIES
BENZOPYRENE
BIOLOGICAL INDICATORS
BIOLOGICAL MARKERS
COMPARATIVE EVALUATIONS
FISHES
GENETIC VARIABILITY
LIVER
METABOLISM
MICROSOMES
WATER POLLUTION