(/sup 3/H)muscimol binding sites increased in autopsied brains of chronic schizophrenics
Journal Article
·
· Life Sci.; (United States)
(/sup 3/H)muscimol binding and glutamic acid decarboxylase (GAD) activity in the prefrontal cortex and caudate nucleus of autopsied brains from 19 chronic schizophrenics and 17 control subjects were investigated. In the schizophrenics, saturation analysis with varying concentrations of (/sup 3/H)muscimol revealed an increase in the number GABA/sub A/ receptors, but there was no significant difference in the affinity. In addition, the enhancement of (/sup 3/H)muscimol binding by diazepam was significantly greater in schizophrenics than in controls. GAD activity did not differ between controls and schizophrenics. The possibility that GABAergic mechanisms might play a role in case of chronic schizophrenia should be given further attention.
- Research Organization:
- Kobe Univ. School of Medicine, Japan
- OSTI ID:
- 7093787
- Journal Information:
- Life Sci.; (United States), Journal Name: Life Sci.; (United States) Vol. 40:3; ISSN LIFSA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550101 -- Behavioral Biology-- Tracer Techniques
550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AFFINITY
BIOCHEMICAL REACTION KINETICS
BODY
BRAIN
CARBON-CARBON LYASES
CARBOXY-LYASES
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM DEPRESSANTS
DECARBOXYLASES
DRUGS
ENZYME ACTIVITY
ENZYMES
ETIOLOGY
ISOTOPE APPLICATIONS
KINETICS
LABELLED COMPOUNDS
LYASES
MEMBRANE PROTEINS
MENTAL DISORDERS
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANS
PATIENTS
PROTEINS
RADIORECEPTOR ASSAY
REACTION KINETICS
RECEPTORS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AFFINITY
BIOCHEMICAL REACTION KINETICS
BODY
BRAIN
CARBON-CARBON LYASES
CARBOXY-LYASES
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM DEPRESSANTS
DECARBOXYLASES
DRUGS
ENZYME ACTIVITY
ENZYMES
ETIOLOGY
ISOTOPE APPLICATIONS
KINETICS
LABELLED COMPOUNDS
LYASES
MEMBRANE PROTEINS
MENTAL DISORDERS
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANS
PATIENTS
PROTEINS
RADIORECEPTOR ASSAY
REACTION KINETICS
RECEPTORS
TRACER TECHNIQUES
TRITIUM COMPOUNDS