Increase in serotonin 5-HT sub 1A receptors in prefrontal and temporal cortices of brains from patients with chronic schizophrenia
- Kobe Univ. School of Medicine (Japan)
Binding studies with ({sup 3}H)8-hydroxy-2-(di-n-propylamino)tetralin (({sup 3}H)8-OH-DPAT), a specific serotonin{sub 1A} (5-HT{sub 1A}) receptor agonist, were done on the autopsied brains from control subjects and from patients with chronic schizophrenia. In the controls, representative Scatchard plots for the specific ({sup 3}H)8-OH-DPAT bindings in the prefrontal cortex and hippocampus revealed a single component of high affinity binding site. The ({sup 3}H)8-OH-DPAT bindings to the prefrontal cortex and hippocampus were potently inhibited by serotonin and 5-HT{sub 1A} agonists, while other neurotransmitters, 5-HT{sub 2} and 5-HT{sub 3} related compounds did not inhibit the binding. The bindings were decreased in the presence of 0.1mM GTP and 0.1mM GppNHp but not in the presence of 0.1mM GMP. In the prefrontal and temporal cortices of schizophrenics, there was a significant increase in the specific ({sup 3}H)8-OH-DPAT binding, by 40% and 60%, respectively, with no change in the hippocampus, amygdala, cingulum, motor cortex, parietal or occipital cortex, as compared to findings in the controls.
- OSTI ID:
- 5915456
- Journal Information:
- Life Sciences; (USA), Vol. 48:4; ISSN 0024-3205
- Country of Publication:
- United States
- Language:
- English
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RECEPTORS
AUTOPSY
BIOCHEMICAL REACTION KINETICS
BRAIN
PATIENTS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
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DISEASES
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MEMBRANE PROTEINS
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ORGANIC COMPOUNDS
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550901* - Pathology- Tracer Techniques