The effect of chronic ethanol on glutamate binding in human and rat brain

Journal Article · Mon Jan 01 04:00:00 EST 1990 · Life Sciences; (USA)

DOI:https://doi.org/10.1016/0024-3205(90)90601-M· OSTI ID:6409030

Cummins, J T; Sack, M; von Hungen, K ^[1]

---

1. V.A. Medical Center, Sepulveda, CA (USA) Univ. of California School of Medicine, Los Angeles (USA)

Quantitative autoradiographic techniques demonstrate that chronic alcohol administration causes a decrease in ({sup 3}H)-glutamate binding to hippocampal N-methyl-D-aspartate (NMDA) receptors. A 14% decrease in ({sup 3}H)-glutamate binding in the hippocampal CA{sub 1} region is seen both in the rat after five days of ethanol administration and in postmortem hippocampal tissues from alcoholics. In the rat, 24 hr ethanol withdrawal values are intermediate between control and alcohol binding levels. There was no significant effect of ethanol on ({sup 3}H)-glutamate binding in the cortex or caudate.

• OSTI ID: 6409030
• Journal Information: Life Sciences; (USA), Journal Name: Life Sciences; (USA) Vol. 47:10; ISSN 0024-3205; ISSN LIFSA
• Country of Publication: United States
• Language: English

Related Subjects

550201 -- Biochemistry-- Tracer Techniques
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALCOHOLS
AMINO ACIDS
ANIMALS
ASPARTIC ACID
AUTORADIOGRAPHY
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
BODY
BRAIN
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM
CHRONIC EXPOSURE
ETHANOL
GLUTAMIC ACID
HYDROGEN COMPOUNDS
HYDROXY COMPOUNDS
ISOTOPE APPLICATIONS
KINETICS
MAMMALS
MAN
MEMBRANE PROTEINS
NERVOUS SYSTEM
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PRIMATES
PROTEINS
RATS
REACTION KINETICS
RECEPTORS
RODENTS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES