Nippostrongylus brasiliensis: phospholipase in nonsensitized and sensitized rats after challenge

Journal Article · Wed Jan 01 04:00:00 EST 1975 · Exp. Parasitol.; (United States)

DOI:https://doi.org/10.1016/0014-4894(75)90042-9· OSTI ID:7091204

Ottolenghi, A ^[1]; Kocan, A A; Weatherly, N F; Larsh, Jr, J E

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1. Duke Univ., Durham, NC

Rats given an initial infection with Nippostrongylus brasiliensis showed greatly elevated phospholipase B levels in the small intestines and lungs from 8 through 22 days after challenge. The rise in enzyme concentration occurred earlier (Days 8-11) in the proximal half of the intestine, but at Days 22, 29, and 36 the levels were much higher in the distal segments. This shift in activity correlates with the known elimination of worms and a diminishing inflammatory response in the proximal areas. The increase in enzyme activity in the intestine and lungs was associated with an increased production of eosinophils in the bone marrow 11-22 days after challenge. Rats sensitized with one stimulating infection before challenge showed an anamnestic type of response, as measured by enzyme levels in the small intestines and lungs and by the numbers of eosinophils in the bone marrow. The results are discussed in light of our similar data reported earlier from animals infected with Trichinella spiralis.

• OSTI ID: 7091204
• Journal Information: Exp. Parasitol.; (United States), Journal Name: Exp. Parasitol.; (United States) Vol. 38; ISSN EXPAA
• Country of Publication: United States
• Language: English

Related Subjects

550200* -- Biochemistry
59 BASIC BIOLOGICAL SCIENCES
ABUNDANCE
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
BONE MARROW
DIGESTIVE SYSTEM
ENZYMES
EOSINOPHILS
ESTERASES
GASTROINTESTINAL TRACT
HEMATOPOIETIC SYSTEM
HYDROLASES
INFECTIVITY
INTESTINES
INVERTEBRATES
LEUKOCYTES
LIPASES
LUNGS
MAMMALS
METABOLISM
NEMATODES
NIPPOSTRONGYLUS
ORGANS
PARASITES
RATS
RESPIRATORY SYSTEM
RODENTS
SMALL INTESTINE
TISSUES
VERTEBRATES