Trichinella spiralis: phospholipase in sensitized mice after challenge

Journal Article · Wed Jan 01 04:00:00 EST 1975 · Exp. Parasitol.; (United States)

DOI:https://doi.org/10.1016/0014-4894(75)90075-2· OSTI ID:7300353

Larsh, Jr, J E ^[1]; Ottolenghi, A; Weatherly, N F

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1. Univ. of North Carolina, Chapel Hill

Mice given three sensitizing infections with Trichinella spiralis and then challenged with 400 larvae showed greatly elevated phospholipase B levels in the small intestine from one through 20 days after challenge; by 25 days after challenge, the enzyme level approached that of the uninfected controls. The high enzyme levels were accompanied, after a lag in time, by greatly increased numbers of eosinophils in the bone marrow. Increases of eosinophils strikingly above those in uninfected controls were noted from 11 through 20 days after challenge. The enzyme and eosinophil increases were parallel to the time course of the intestinal inflammatory response described in a previous study of sensitized mice of about the same age challenged with the same number of larvae. The results are consistent with our hypothesis that inflammation, elevated enzyme levels, and increased production of eosinophils are causally related.

• OSTI ID: 7300353
• Journal Information: Exp. Parasitol.; (United States), Journal Name: Exp. Parasitol.; (United States) Vol. 37; ISSN EXPAA
• Country of Publication: United States
• Language: English

Related Subjects

550600* -- Medicine
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
BONE MARROW
DIGESTIVE SYSTEM
DISEASES
ENZYMES
EOSINOPHILS
GASTROINTESTINAL TRACT
HELMINTHS
HEMATOPOIETIC SYSTEM
INFECTIOUS DISEASES
INTESTINES
INVERTEBRATES
LEUKOCYTES
MAMMALS
MICE
NEMATODES
ORGANS
PARASITES
RODENTS
SMALL INTESTINE
TISSUES
TRICHINELLA
VERTEBRATES