Trichinella spiralis: phospholipase in challenged mice and rats

Journal Article · Tue Jan 01 04:00:00 EST 1974 · Exp. Parasitol.; (United States)

DOI:https://doi.org/10.1016/0014-4894(74)90069-1· OSTI ID:7218578

Larsh, Jr, J E ^[1]; Ottolenghi, A; Weatherly, N F

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1. Univ. of North Carolina, Chapel Hill

Mice challenged with 400 larvae of T. spiralis showed greatly elevated phospholipase levels in tissues of the small intestine from 5 to 29 days after infection, after which the levels returned to those of the uninfected controls. Related to these rises in enzyme levels were greatly increased numbers of eosinophils in the bone marrow. Increases strikingly above those in the controls were noted from 8 to 20 days after infection. In rats challenged with 3000 larvae, the enzyme levels were elevated from 4 to 18 days, and the eosinophils were increased during the same periods. A working hypothesis is proposed to explain these phenomena.

• OSTI ID: 7218578
• Journal Information: Exp. Parasitol.; (United States), Journal Name: Exp. Parasitol.; (United States) Vol. 36; ISSN EXPAA
• Country of Publication: United States
• Language: English

Related Subjects

550900* -- Pathology
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
BONE MARROW
CORRELATIONS
DISEASES
ENZYMES
EOSINOPHILS
HELMINTHS
HEMATOPOIETIC SYSTEM
INFECTIOUS DISEASES
INVERTEBRATES
LEUKOCYTES
MAMMALS
MICE
NEMATODES
ORGANS
PARASITES
RATS
RODENTS
TISSUES
TRICHINELLA
VERTEBRATES