Evaluation of the hemodynamic effects of intravenous administration of ionic and nonionic contrast materials: implications for deriving physiologic measurements from computed tomography and digital cardiovascular imaging

Journal Article · Mon Mar 01 04:00:00 EST 1982 · Radiology; (United States)

DOI:https://doi.org/10.1148/radiology.142.3.7063684· OSTI ID:7088701

Higgins, C B; Berber, K H; Mattrey, R F; Slutsky, R A

The effects of intravenous injection of an ionic contrast material (Renografin-76 (meglumine sodium diatrizoate)) on left ventricular pressure, internal diameter, and wall thickness, and on coronary and femoral hemodynamics were compared with those of a hydrolytically stable nonionic contrast material (iohexol). Renografin-76 caused drastic biphasic changes in left ventricular pressure and dp/dt (rate of change of left ventricular pressure), and moderate changes in end systolic dimension. Iohexol caused little or no change in left ventricular pressure and dimensions. In addition, Renografin-76 caused marked arterial hypotension and large increases in coronary and femoral blood lows, while iohexol caused no significant change in arterial pressure and coronary blood flow, and a mild increase in femoral blood flow. Based on these findings, it is concluded that iohexol is preferable to standard ionic contrast material for deriving basal physiologic information from computed tomographic and digital vascular studies.

• Research Organization: Univ. of California, San Diego
• OSTI ID: 7088701
• Journal Information: Radiology; (United States), Journal Name: Radiology; (United States) Vol. 142:3; ISSN RADLA
• Country of Publication: United States
• Language: English

Related Subjects

550602* -- Medicine-- External Radiation in Diagnostics-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
BIOLOGICAL EFFECTS
BLOOD FLOW
BODY
CARDIOVASCULAR SYSTEM
COMPARATIVE EVALUATIONS
COMPUTERIZED TOMOGRAPHY
CONTRAST MEDIA
DIAGNOSTIC TECHNIQUES
DYNAMIC FUNCTION STUDIES
HEART
INJECTION
INTAKE
INTRAVENOUS INJECTION
ORGANS
TOMOGRAPHY