Cardiovascular effects of metrizamide in infants
Journal Article
·
· Radiology; (United States)
A prospective study was performed in 30 children under 3 years of age to compare the cardiovascular effects of a nonionic contrast material of low osmolality, metrizamide, with those of a conventional ionic contrast material, meglumine sodium diatrizoate. Left ventricular end-diastolic pressure, left ventricular peak systolic pressure, heart rate, echocardiographically obtained end-diastolic and end-systolic dimension, and blood chemistries were obtained before and after angiography. Neither contrast material changed serum sodium, potassium, or creatinine levels. However, serum osmolality rose significantly following injection of diatrizoate, but not metrizamide. Both end-diastolic and end-systolic dimensions increased after diatrizoate injection. However, end-diastolic dimension was unchanged and end-systolic dimension fell after metrizamide infusion. It is concluded that although the effects on intracardiac pressures are similar for both contrast materials, metrizamide may be advantageous in the critically ill infant because it causes a smaller increase in osmolality, fewer changes in cardiac dimensions, and a reduced heart rate challenge.
- Research Organization:
- Univ. of California, Los Angeles
- OSTI ID:
- 6603202
- Journal Information:
- Radiology; (United States), Journal Name: Radiology; (United States) Vol. 148: 3; ISSN RADLA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550602* -- Medicine-- External Radiation in Diagnostics-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
AGE GROUPS
AMIDES
BIOLOGICAL EFFECTS
BIOMEDICAL RADIOGRAPHY
BLOOD CHEMISTRY
BLOOD PRESSURE
CARDIOVASCULAR SYSTEM
CHILDREN
CONTRAST MEDIA
DIAGNOSTIC TECHNIQUES
MEDICINE
METRIZAMIDE
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
RADIOLOGY
62 RADIOLOGY AND NUCLEAR MEDICINE
AGE GROUPS
AMIDES
BIOLOGICAL EFFECTS
BIOMEDICAL RADIOGRAPHY
BLOOD CHEMISTRY
BLOOD PRESSURE
CARDIOVASCULAR SYSTEM
CHILDREN
CONTRAST MEDIA
DIAGNOSTIC TECHNIQUES
MEDICINE
METRIZAMIDE
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
RADIOLOGY