Contrast agents for cardiac angiography: effects of a nonionic agent vs. a standard ionic agent

Conference · Sat Dec 01 04:00:00 EST 1984 · Radiology; (United States)

OSTI ID:5615517

Bettmann, M A; Bourdillon, P D; Barry, W H; Brush, K A; Levin, D C

The effects on cardiac hemodynamics and of a standard contrast agent, sodium methylglucamine diatrizoate (Renografin 76) were compared with the effects of a new nonionic agent (iohexol) in a double-blind study in 51 patietns undergoing coronary angiography and left ventriculography. No significant alteration in measured blood parameters occurred with either contrast agent. Hemodynamic changes occurred with both, but were significantly greater with the standard renografin than with the low-osmolality, nonionic iohexol. After left ventriculography, heart rate increased and peripheral arterial pressure fell with both agents, but less with iohexol. It is concluded that iohexol causes less alteration in cardiac function than does the agent currently most widely used. Nonionic contrast material is likely to improve the safety of coronary angiography, particularly in those patients at greatest risk.

• Research Organization: Harvard Medical School/Brigham and Women's Hospital, Boston, MA
• OSTI ID: 5615517
• Report Number(s): CONF-8211184-
• Conference Information: Journal Name: Radiology; (United States) Journal Volume: 153:3
• Country of Publication: United States
• Language: English

Related Subjects

550602* -- Medicine-- External Radiation in Diagnostics-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
BIOLOGICAL EFFECTS
BIOMEDICAL RADIOGRAPHY
BLOOD PRESSURE
BODY
CARDIOVASCULAR SYSTEM
CONTRAST MEDIA
DIAGNOSTIC TECHNIQUES
HEART
IOHEXOL
MEDICINE
NUCLEAR MEDICINE
ORGANS
PATIENTS
RADIOLOGY