Survival of mouse mammary gland transplants of normal, hyperplastic, and tumor tissues exposed to X-rays

Journal Article · Thu Apr 01 00:00:00 EST 1982 · J. Natl. Cancer Inst.; (United States)

OSTI ID:7085330

Faulkin, L J; Mitchell, D J; Cardiff, R D; Goldman, M

Mouse mammary tissues, including ducts, prelactating lobules, hyperplastic outgrowth lines, and tumors, were exposed to varying doses of X-rays and then transplanted to fat pads of nonirradiated BALB/c mice for study. Estimates of the dose of radiation that would allow survival of 50% of the transplants (SD50) were made with the use of probit analysis. Nearly all duct and lobule transplants survived doses of X-rays from 0 to 800 rad. The survival rate declined rapidly following doses above 800 rad, and the calculated SD50 was 1,020 and 1,260 rad for mammary ducts and lobules, respectively. The three hyperplastic outgrowth lines tested gave very different results. Hyperplastic line Z5C1 transplants had better than 90% survival at doses up to 1,200 rad and an SD50 between 1,200 and 1,600 rad. Hyperplastic line Z5D transplants had an SD50 of between 800 and 1,200 rad. Hyperplastic line D1 transplants had a better than 90% survival following doses of 0-600 rad and an SD50 between 600 and 800 rad. The survival of tumor transplants was 100% following doses of X-rays up to 1,200 rad; the SD50 was in excess of 1,600 rad. The mouse mammary transplantation system can be used to study the direct effect of X-rays on normal, premalignant, and malignant mammary tissues and provides a basis for the study of the radiobiology of mammary tissues.

• Research Organization: School of Veterinary Medicine, University of California, Davis
• OSTI ID: 7085330
• Journal Information: J. Natl. Cancer Inst.; (United States), Vol. 68:4
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
62 RADIOLOGY AND NUCLEAR MEDICINE
MAMMARY GLANDS
BIOLOGICAL RADIATION EFFECTS
DOSE-RESPONSE RELATIONSHIPS
MICE
RADIATION DOSES
RADIOBIOLOGY
TRANSPLANTS
X RADIATION
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGY
BODY
DOSES
ELECTROMAGNETIC RADIATION
GLANDS
IONIZING RADIATIONS
MAMMALS
ORGANS
RADIATION EFFECTS
RADIATIONS
RODENTS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals
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