Effects of X irradiation on the growth of normal and hyperplastic mouse mammary gland transplants

Journal Article · Sun May 01 04:00:00 EDT 1983 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3575972· OSTI ID:5504597

Faulkin, L J; Mitchell, D J; Cardiff, R D; Rosenblatt, L S; Goldman, M

To avoid the problems associated with whole-body radiation, pieces of X-irradiated normal or hyperplastic mammary tissue were transplanted to the host gland-free fat pad of nonexposed mice. The percentage of the fat pad filled by growth of the transplants at 4, 8, and 12 weeks after transplanation was measured. Growth of lobule transplants was moderately inhibited by 4 Gy. While some of the lobules survived 12 Gy, their growth was severely inhibited. The hyperplastic outgrowth lines were variable but more resitant than lobules to growth retardiation. Line Z5D was more susceptible than D/sub 1/, and Z5C/sub 1/ was least susceptible, with 88% growing well after 12 Gy. In order to distinguish between transient and permainent growth retardation, tissue was taken from the irradiated and control transplants and retransplanted to new hosts without further radiation. The second generation of X-ray-exposed tissue filled more of the fat pad than the first-generation transplants, but significantly less than the nonexposed controls. The experiments described provide a means of demonstrating X-ray-induced changes in the mammary gland from growth inhibition to carcinogenesis.

• OSTI ID: 5504597
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 94:2; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
ELECTROMAGNETIC RADIATION
GLANDS
GROWTH
INHIBITION
IONIZING RADIATIONS
MAMMALS
MAMMARY GLANDS
MATHEMATICS
MICE
ORGANS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RODENTS
STATISTICS
TRANSPLANTS
VERTEBRATES
X RADIATION