Subchronic oral administration of gossypol-acetic acid (GAA) alters the distribution and utilization of radioiron in male rats

Journal Article · Wed Jun 01 00:00:00 EDT 1988 · Drug Chem. Toxicol.; (United States)

DOI:https://doi.org/10.3109/01480548808998218· OSTI ID:7069882

Reynolds, J M; Tone, J N

Gossypol-acetic acid (GAA) has been shown to be a powerful chelator of iron. To determine how subchronic administration of GAA affects the distribution and utilization of radioiron, male Holtzman rats, which had received a daily oral dose of GAA (20 mg/kg body weight) for 16 weeks, were injected i.p. with (/sup 59/Fe)citrate (activity = 16.5 muCi/kg body weight) and (/sup 59/Fe) incorporation into circulating erythrocytes, bone marrow, liver, spleen, skeletal muscle, and urine was measured 6, 12, or 24 h after (/sup 59/Fe) administration. Iron (/sup 59/Fe) incorporation was enhanced in the spleens, livers, bone marrow, and blood of the GAA-treated rats, and increased as the time post-(/sup 59/Fe) injection increased. Hematological parameters remained within normal limits throughout the 16-week treatment period, suggesting an erythropoietic compensation in the GAA-treated rats. Iron status was markedly different in the GAA-treated rats at the end of the 16 week treatment period, suggesting altered iron utilization. The data suggest that (/sup 59/Fe) is preferentially distributed to the erythroid tissues of GAA-treated rats for utilization in erythropoiesis.

• Research Organization: Illinois State Univ., Normal (USA)
• OSTI ID: 7069882
• Journal Information: Drug Chem. Toxicol.; (United States), Journal Name: Drug Chem. Toxicol.; (United States) Vol. 11:2; ISSN DCTOD
• Country of Publication: United States
• Language: English

Related Subjects

550501 -- Metabolism-- Tracer Techniques
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACETIC ACID
ANIMAL TISSUES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
BONE MARROW
CARBOXYLIC ACIDS
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISTRIBUTION
ELEMENTS
ERYTHROCYTES
EVEN-ODD NUCLEI
GLANDS
HEMATOPOIETIC SYSTEM
INTERMEDIATE MASS NUCLEI
IRON
IRON 59
IRON ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LIVER
MAMMALS
MATERIALS
METABOLISM
METALS
MONOCARBOXYLIC ACIDS
NUCLEI
ORAL ADMINISTRATION
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPES
RATS
RODENTS
SPLEEN
TISSUE DISTRIBUTION
TISSUES
TRACER TECHNIQUES
TRANSITION ELEMENTS
VERTEBRATES