Effect of gossypol-acetic acid on radioiron utilization in male rats

Thesis/Dissertation · Mon Dec 31 23:00:00 EST 1984

OSTI ID:6024109

Reynolds, J M

Mature male Holtzman rats (112 days old) were fed gossypolacetic acid (GAA, 20 mg/kg body weight) daily for 16 weeks in order to determine changes in hematology, reproductive performance, and iron (/sup 59/Fe) utilization. Free, bound, and total gossypol concentrations of various organs were also determined. Male rats were infertile after 16 weeks of treatment. Mean body weight gains of GAA treated rats were significantly less than the mean body weight gains of control rats throughout the 16 week treatment period. Free and bound gossypol were found in all organs that were analyzed. Hematological parameters remained within normal limits throughout the 16 week treatment period. Iron (/sup 59/Fe) incorporation was enhanced in the spleens, livers, bone marrow, and blood of GAA treated rats, and increased as the time after /sup 59/Fe administration increased. Splenic compensation was responsible for maintenance of normal hematology and changes in iron distribution in GAA treated rats.

• Research Organization: Illinois State Univ., Normal (USA)
• OSTI ID: 6024109
• Country of Publication: United States
• Language: English

Related Subjects

560172* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACETIC ACID
ANIMAL TISSUES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BODY
BODY FLUIDS
BONE MARROW
CARBOXYLIC ACIDS
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISTRIBUTION
EVEN-ODD NUCLEI
FERTILITY
GLANDS
HEMATOPOIETIC SYSTEM
INTERMEDIATE MASS NUCLEI
IRON 59
IRON ISOTOPES
ISOTOPES
LIVER
MAMMALS
MATERIALS
MONOCARBOXYLIC ACIDS
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPES
RADIONUCLIDE KINETICS
RATS
RODENTS
SPLEEN
TISSUE DISTRIBUTION
TISSUES
VERTEBRATES