Influence of ascorbic acid (AA) on iron (Fe) utilization in copper (Cu) deficient male and female rats

Journal Article · Thu Feb 09 04:00:00 EST 1989 · FASEB Journal (Federation of American Societies for Experimental Biology); (USA)

OSTI ID:6831737

Johnson, M A ^[1]

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1. Univ. of Georgia, Athens (USA)

Interactions between Cu status (-Cu: 1.0 mg Cu/kg diet or +Cu: 5.8 mg Cu/kg diet) and AA (0 or 1% of the diet) were compared in male and female weanling rats. Food intakes were controlled so that final body weights were similar on day 23 when rats were killed. On day 17 rats were given an oral dose of 4 uCi of Fe-59 and feces were collected for 5 days. Heart weights (g/100 g body weight) were increased in both male and female -Cu rats. Among -Cu rats, AA increased heart weight by 25% in females but by only 6% in males. Similarly, among -Cu rats AA increased liver weight (g/100 g body weight) by 16% in females but not at all in males. Hematocrits (%) were similar among +Cu rats but were decreased in -Cu rats to a greater in male than in female rats. However, among -Cu rats AA decreased hematocrits from 34.1 to 26.4% in females but from only 30.0 to 26.8% in males. Compared to -Cu rats, +Cu rats apparently absorbed 2-times more Fe-59 and retained 2.5- times more absorbed Fe-59 in their whole blood. Among -Cu rats, AA decreased the absorption of Fe-59 and whole blood Fe-59 to a greater extent in female than in male rats. These results suggest that female rats may be somewhat more sensitive to the adverse effects of AA during Cu deficiency than are male rats.

• OSTI ID: 6831737
• Journal Information: FASEB Journal (Federation of American Societies for Experimental Biology); (USA), Journal Name: FASEB Journal (Federation of American Societies for Experimental Biology); (USA) Vol. 3:3; ISSN FAJOE; ISSN 0892-6638
• Country of Publication: United States
• Language: English

Related Subjects

550501 -- Metabolism-- Tracer Techniques
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ASCORBIC ACID
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BODY
BODY FLUIDS
CARDIOVASCULAR SYSTEM
COPPER
DAYS LIVING RADIOISOTOPES
DIET
DIGESTIVE SYSTEM
ELEMENTS
EVEN-ODD NUCLEI
GLANDS
HEART
INTERMEDIATE MASS NUCLEI
IRON
IRON 59
IRON ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
KINETICS
LIVER
MAMMALS
MATERIALS
METALS
NUCLEI
NUTRITIONAL DEFICIENCY
ORGANS
RADIOISOTOPES
RATS
REACTION KINETICS
RETENTION
RODENTS
SEX DEPENDENCE
TRACER TECHNIQUES
TRANSITION ELEMENTS
VERTEBRATES
VITAMINS
WEIGHT