Radioiron utilization and gossypol acetic acid in male rats

Journal Article · Tue Jan 01 04:00:00 EST 1985 · Drug Chem. Toxicol.; (United States)

DOI:https://doi.org/10.3109/01480548509011635· OSTI ID:6334076

Tone, J N; Jensen, D R

The 24-h incorporation of VZFe into circulating red blood cells, bone marrow, urine, liver, spleen, and skeletal muscle was measured in splenectomized and sham-splenectomized rats which had received a daily, oral dose of gossypol acetic acid (20 mg GAA/kg body wt) for 91 days. A significant decrease in total body weight gain was observed in all GAA treated animals. Splenectomized rats dosed with GAA exhibited a significant decrease in hemoglobin concentration, hematocrit and erythrocyte count. A significant increase in VZFe incorporation by red blood cells and a decrease in hepatic incorporation of VZFe indicate a preferential utilization of iron in erythropoiesis among GAA treated animals.

• Research Organization: Illinois State Univ., Normal
• OSTI ID: 6334076
• Journal Information: Drug Chem. Toxicol.; (United States), Journal Name: Drug Chem. Toxicol.; (United States) Vol. 1-2; ISSN DCTOD
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMAL TISSUES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BLOOD
BLOOD CELLS
BLOOD FORMATION
BODY
BODY FLUIDS
BONE MARROW
CELL KILLING
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DRUGS
ERYTHROCYTES
ERYTHROPOIESIS
EVEN-ODD NUCLEI
GAMETES
GERM CELLS
GLANDS
HEMATOPOIETIC SYSTEM
INTERMEDIATE MASS NUCLEI
IRON 59
IRON COMPOUNDS
IRON ISOTOPES
ISOTOPES
LIVER
MAMMALS
MATERIALS
MEDICINE
METABOLISM
MUSCLES
NUCLEI
ORGANS
RADIOISOTOPES
RATS
RODENTS
SPERMATOZOA
SPLEEN
SPLENECTOMY
SURGERY
TISSUES
TRANSITION ELEMENT COMPOUNDS
URINE
VERTEBRATES
WASTES
WEIGHT