Hematopoiesis and aging. IV. Mass and distribution of erythroid marrow in aged mice
Journal Article
·
· Exp. Hematol.; (United States)
OSTI ID:6258127
Aged mice are ''anemic,'' i.e., they have a lower hematocrit than young adult mice, but this appears to be a ''dilutional'' anemia; the red cell mass is normal. Other observations have supported the hypothesis that basal erythropoiesis does not change as mice grow old. In the present study, the percentage of injected VZFe found in the skeleton and spleen, VZFe distribution between various bones and bone groups, and the number of nucleated erythroid cells per humerus were studied and the total mass of erythroid precursors was calculated. There was no significant difference in any of these values between mice aged 3-27 months. The variability of VZFe distribution within various skeletal parts was no greater in aged than in young mice. Thus, these data further strengthen the case for normal basal rates of erythropoiesis in aged mice.
- Research Organization:
- Univ. of Pittsburgh School of Medicine, PA
- OSTI ID:
- 6258127
- Journal Information:
- Exp. Hematol.; (United States), Journal Name: Exp. Hematol.; (United States) Vol. 10; ISSN EXHMA
- Country of Publication:
- United States
- Language:
- English
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OSTI ID:6788387
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Sat Mar 31 23:00:00 EST 1984
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Sat Dec 31 23:00:00 EST 1977
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OSTI ID:5705283
Related Subjects
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AGE DEPENDENCE
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD FORMATION
BODY
BONE MARROW
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISTRIBUTION
ERYTHROPOIESIS
EVEN-ODD NUCLEI
GLANDS
HEMATOPOIETIC SYSTEM
INTERMEDIATE MASS NUCLEI
IRON 59
IRON ISOTOPES
ISOTOPES
LIVER
MAMMALS
MICE
NUCLEI
ORGANS
RADIOISOTOPES
RODENTS
SKELETON
SOMATIC CELLS
SPLEEN
STEM CELLS
TISSUE DISTRIBUTION
TISSUES
VERTEBRATES
62 RADIOLOGY AND NUCLEAR MEDICINE
AGE DEPENDENCE
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD FORMATION
BODY
BONE MARROW
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISTRIBUTION
ERYTHROPOIESIS
EVEN-ODD NUCLEI
GLANDS
HEMATOPOIETIC SYSTEM
INTERMEDIATE MASS NUCLEI
IRON 59
IRON ISOTOPES
ISOTOPES
LIVER
MAMMALS
MICE
NUCLEI
ORGANS
RADIOISOTOPES
RODENTS
SKELETON
SOMATIC CELLS
SPLEEN
STEM CELLS
TISSUE DISTRIBUTION
TISSUES
VERTEBRATES