Hematopoiesis and aging. V. A decline in hematocrit occurs in all aging female B6D2F1 mice

Journal Article · · Exp. Aging Res.; (United States)

OSTI ID:6788387

Boggs, D R; Patrene, K

Longitudinal studies of hematocrits were done in aging B6D2F1 female mice at 54, 64, 91, 105 and 115 weeks of age. A modest decline in hematocrit was observed in 41/42 mice; we have previously shown that the decreased hematocrit of aged as compared to young mice is due to an expansion of plasma volume. Mice which died spontaneously after 91 weeks had lower hematocrits at 91 weeks and 105 weeks than did those which survived to 115 weeks. At each time interval, a sub-group of mice was killed and uptake of /sup 59/Fe into blood, foreleg, spleen and liver was studied and total nucleated cells per humerus was determined. The results were generally compatible with the thesis that aging mice maintain normal rates of erythropoiesis under basal conditions. Thus, it would appear that a decrease in hematocrit can be considered an expected part of the aging process in this mouse.

• Research Organization: Univ. of Pittsburgh, PA
• OSTI ID: 6788387
• Journal Information: Exp. Aging Res.; (United States), Journal Name: Exp. Aging Res.; (United States) Vol. 3; ISSN EAGRD
• Country of Publication: United States
• Language: English

Related Subjects

551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AGING
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD CHEMISTRY
BLOOD FORMATION
DAYS LIVING RADIOISOTOPES
EVEN-ODD NUCLEI
INTERMEDIATE MASS NUCLEI
IRON 59
IRON COMPOUNDS
IRON ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MICE
NUCLEI
RADIOISOTOPES
RODENTS
TRACER TECHNIQUES
TRANSITION ELEMENT COMPOUNDS
UPTAKE
VERTEBRATES