THE EFFECTS OF ACUTE PROTEIN DEPLETION ON THE DISTRIBUTION OF RADIOIRON IN RAT TISSUES
The distribution of Fe/sup 59/ in plasma, bone marrow, erythrocytes, liver, and spleen was determined at specified intervals after single intravenous injections of the radioisotope into normal and protein-deficient rats. In normal rats, injected radioiron followed the usual metabolic pathways; i.e., through bone marrow to erythrocytes, with small, consistent amounts to liver and spleen. In protein-deficient animals normal Fe/sup 59/ time-concentration relationships were disrupted completely. Less iron was recovered from the tissues of protein- deficient rats than from normal animals. Storage iron in liver and spleen was not conjugated with polysaccharide, even though tissue protein was seriously depleted. (auth)
- Research Organization:
- Argonne Cancer Research Hospital, Chicago; Argonne National Lab., Lemont, Ill.
- NSA Number:
- NSA-12-011285
- OSTI ID:
- 4339358
- Journal Information:
- Blood (U.S.), Journal Name: Blood (U.S.) Vol. Vol: 8, No. 2; ISSN BLOOA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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