A correlative study of clinical-pathologic characteristics of human brain tumors and blood brain barrier (BBB) permeability evaluated with Ga-68 EDTA and positron emission tomography
Conference
·
· J. Nucl. Med.; (United States)
OSTI ID:7064642
The authors investigated the relationship between quantitative estimates of BBB permeability and the clinical and pathologic characteristics of human brain tumors. BBB permeability in 12 patients with either primary (4) or metastatic (8) brain tumors were studied with Ga-68 EDTA and PET with a two compartment model. The clinical and pathologic characteristics of the tumors were reviewed retrospectively. PET estimates of the transfer constant K/sub 1/ (ml/min/gm) paralleled the X-ray CT evidence of BBB disruption. Biopsies of four patients provided histologic support for the presumed pathophysiologic mechanism of BBB disruption, in the degree of alteration of brain vascularity and cellular architecture. For example, a patient with a hemorrhagic melanoma and a K/sub 1/ = 0.0049 ml/min/gm had gross hemorrhage, little recognizeable brain tissue and evidence of neovascularization on biopsy.
- Research Organization:
- UCLA School of Medicine, Los Angeles, CA
- OSTI ID:
- 7064642
- Report Number(s):
- CONF-850611-
- Conference Information:
- Journal Name: J. Nucl. Med.; (United States) Journal Volume: 26:5
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550100 -- Behavioral Biology
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
550602 -- Medicine-- External Radiation in Diagnostics-- (1980-)
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINO ACIDS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOPSY
BLOOD FLOW
BLOOD-BRAIN BARRIER
BODY
BRAIN
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM
CHELATING AGENTS
COMPUTERIZED TOMOGRAPHY
CORRELATIONS
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DISEASES
EDTA
EMISSION COMPUTED TOMOGRAPHY
GALLIUM 68
GALLIUM ISOTOPES
HEMORRHAGE
HISTOLOGY
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOTOPES
LABELLING
NEOPLASMS
NERVOUS SYSTEM
NUCLEI
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PATHOLOGY
PATIENTS
PERMEABILITY
PHYSIOLOGY
POSITRON COMPUTED TOMOGRAPHY
RADIOISOTOPES
SYMPTOMS
TOMOGRAPHY
USES
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
550602 -- Medicine-- External Radiation in Diagnostics-- (1980-)
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINO ACIDS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOPSY
BLOOD FLOW
BLOOD-BRAIN BARRIER
BODY
BRAIN
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM
CHELATING AGENTS
COMPUTERIZED TOMOGRAPHY
CORRELATIONS
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DISEASES
EDTA
EMISSION COMPUTED TOMOGRAPHY
GALLIUM 68
GALLIUM ISOTOPES
HEMORRHAGE
HISTOLOGY
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOTOPES
LABELLING
NEOPLASMS
NERVOUS SYSTEM
NUCLEI
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PATHOLOGY
PATIENTS
PERMEABILITY
PHYSIOLOGY
POSITRON COMPUTED TOMOGRAPHY
RADIOISOTOPES
SYMPTOMS
TOMOGRAPHY
USES