The effects of ionizing radiation and dexamethasone on the blood-brain-barrier (BBB) and blood-tumor-barrier (BTB): Implications for boron neutron capture therapy (BNCT) of brain tumors

Conference · Fri Jan 01 04:00:00 EST 1988

OSTI ID:6540749

Dorn, III, R V; Spickard, J H; Griebenow, M L

Currently envisioned techniques for Boron Neutron Capture Therapy (BNCT) of brain tumors rely on the increased permeability of the blood-brain-barrier (BBB) (more specifically, the blood-tumor-barrier (BTB)) which occurs around the malignant tumor. As a result of this increased permeability, higher boron concentrations (Na/sub 2/B/sub 12/H/sub 11/SH) should be obtainable in the tumor than in the surrounding normal brain. The effects on the BBB and BTB by the ionizing component of this radiation and by the steroid dexamethasone (almost universally used in the clinical management of these patients) must be considered in the formulation of this treatment technique. 32 refs., 5 tabs.

• Research Organization: EG and G Idaho, Inc., Idaho Falls (USA)
• DOE Contract Number: AC07-76ID01570
• OSTI ID: 6540749
• Report Number(s): EGG-M-88039; CONF-8805150-2; ON: DE89005175
• Country of Publication: United States
• Language: English

Related Subjects

560151 -- Radiation Effects on Animals-- Man
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADRENAL HORMONES
ANIMALS
BIOLOGICAL EFFECTS
BLOOD-BRAIN BARRIER
BODY
BORON COMPOUNDS
BRAIN
CATS
CENTRAL NERVOUS SYSTEM
CORTICOSTEROIDS
DEXAMETHASONE
DISEASES
DOGS
DOSE-RESPONSE RELATIONSHIPS
GLUCOCORTICOIDS
HUMAN POPULATIONS
HYDROXY COMPOUNDS
IONIZING RADIATIONS
KETONES
MAMMALS
MEDICINE
NEOPLASMS
NERVOUS SYSTEM
NEUTRON CAPTURE THERAPY
NEUTRON THERAPY
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANS
PERMEABILITY
POPULATIONS
PREGNANES
RADIATIONS
RADIOLOGY
RADIOTHERAPY
RATS
RODENTS
STEROIDS
THERAPY
VERTEBRATES