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The effect of ionizing radiation on the blood-brain-barrier (BBB): Considerations for the application of Boron Neutron Capture Therapy (BNCT) of brain tumors

Conference ·
OSTI ID:6798221
; ;
All methods of Boron Neutron Capture Therapy (BNCT) in use or envisioned for treatment of brain tumors have an element of ionizing radiation (incident and induced). This paper reviews data on the effects of ionizing radiation on the blood-brain-barrier (BBB) and the blood-tumor-barrier (BTB) and the potential impact of the effects on the delivery techniques of BNCT. The objectives are: review the available technique for BNCT of brain tumors; review the literature on experimental and human studies regarding the effects of ionizing radiation on the BBB; discuss the impact of these effects on the fractionization question for BNCT; and draw conclusions from that information. 22 refs., 4 tabs.
Research Organization:
EG and G Idaho, Inc., Idaho Falls (USA)
DOE Contract Number:
AC07-76ID01570
OSTI ID:
6798221
Report Number(s):
EGG-M-88104; CONF-8802102-2; ON: DE89005177
Country of Publication:
United States
Language:
English

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Related Subjects

550603* -- Medicine-- External Radiation in Therapy-- (1980-)
560151 -- Radiation Effects on Animals-- Man
560152 -- Radiation Effects on Animals-- Animals
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BLOOD-BRAIN BARRIER
BODY
BORON COMPOUNDS
BRAIN
CENTRAL NERVOUS SYSTEM
DISEASES
DOCUMENT TYPES
DOSE-RESPONSE RELATIONSHIPS
IONIZING RADIATIONS
LABORATORY ANIMALS
MAMMALS
MAN
MEDICINE
NEOPLASMS
NERVOUS SYSTEM
NEUTRON CAPTURE THERAPY
NEUTRON THERAPY
NUCLEAR MEDICINE
ORGANS
PRIMATES
RADIATION EFFECTS
RADIATIONS
RADIOLOGY
RADIOTHERAPY
REVIEWS
THERAPY
VERTEBRATES