Gallium-68 ethylenediamine tetraacetic acid (EDTA) imaging of brain tumors by positron tomography

Conference · Sun Jan 01 04:00:00 EST 1984 · J. Nucl. Med.; (United States)

OSTI ID:7087843

Wong, D F; Inoue, Y; Rosenbloom, S; Wharam, M; Carson, B; Wagner, Jr, H N

While noncontrast CT demonstrates the effects of brain tumors, such as regions surrounding the tumors with low CT numbers, contrast is often required to show the tumor itself. Unfortunately, contrast may cause seizures in 9-15% of patients with brain metastases. Contrast enters the tumor region because of absence of the blood-brain barrier (BBB). Chelates have been used in planar nuclear imaging to study BBB integrity, but have not been used widely in position tomography. The authors carried out positron tomography (PET) with Ga-68 EDTA in 22 patients with suspected or proven brain tumors. In l3/22, the lesions were detected equally well by contract CT and PET. In 3/22 the lesions were more clearly visualized with PET than contrast CT. In 1 case, there as a more extensive abnormality on PET than on contract CT. In 2 post-operating patients, the presence of tumor was detected by contrast CT and PET, but interference from surgical clips obscured the CT but not the PET images. Indications for positron tomography with Ga-68 EDTA include allergy to contrast media, history of seizures with contrast media, or interfering opacities such as surgical clips or calcifications. An important characteristic of Ga-68 EDTA is that it is easily eluted from a long lived Ge-68 generator. Furthermore, GA-68 EDTA can be used to quantify BBB integrity with the appropriate modelling, e.g. as in steroid therapy.

• Research Organization: The Johns Hopkins Medical Institutions, Baltimore, MD
• OSTI ID: 7087843
• Report Number(s): CONF-840619-
• Conference Information: Journal Name: J. Nucl. Med.; (United States) Journal Volume: 25:5
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
ALLERGY
AMINO ACIDS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BODY
BODY FLUIDS
BRAIN
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM
CHELATING AGENTS
COMPUTERIZED TOMOGRAPHY
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DISEASES
EDTA
EMISSION COMPUTED TOMOGRAPHY
GALLIUM 68
GALLIUM ISOTOPES
HOURS LIVING RADIOISOTOPES
IMAGE PROCESSING
IMAGES
INTERMEDIATE MASS NUCLEI
ISOTOPES
LABELLING
MATERIALS
METASTASES
NEOPLASMS
NERVOUS SYSTEM
NUCLEI
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PATIENTS
POSITRON COMPUTED TOMOGRAPHY
PROCESSING
RADIOISOTOPES
TOMOGRAPHY
USES