Simultaneous estimations of blood brain barrier (BBB) permeability and local cerebral blood volume (CBV) in human brain tumors with positron tomography and Ga-68 EDTA

Conference · Sun Jan 01 04:00:00 EST 1984 · J. Nucl. Med.; (United States)

OSTI ID:6590988

Hawkins, R A; Phelps, M E; Huang, S C; Wapenski, J A; Grimm, P D; Greenberg, P; Parker, R G; Juillard, G; Kuhl, D E

Using Ga-68 EDTA and a two compartment model for diffusion across the BBB that includes a weighted subtraction term for determination of the relative CBV (compared to a normal region of brain with an intact BBB) or the absolute value of CBV (using measurements of Ga-68 concentrations in the blood: the input function), the authors determined values for the forward and reverse rate constants (k1 and k2) for diffusion across the BBB as well as values of CBV in 12 subjects with primary or metastatic brain tumors. Patients were studied on a NeuroECAT tomograph; imaging times were 1 to 10 minutes per scan for a total of about 2 hours. Measurements of Ga-68 concentrations were made on plasma arterial samples. Four direct measurements (in 3 subjects) of CBV using C(15-0) were also obtained. Values of k1 (the transfer constant which numerically approximates the capillary permeability surface area (PS) product) averaged 0.0030 (+- 0.0017) ml/min/gm while k2 averaged 0.0308 (+- 0.0157)/min. Linear regression analysis of the relative CBV in 7 tumor deposits in 4 paired Ga-68 EDTA/C(15-0) studies compared to normal brain tissues resulted in a correlation coefficient of 0.97 for the two methods. The estimates of k1 and k2 were insensitive to changes in the location of the control regions (although CBV estimates changed appropriately) as well as to substituting the input function for a normal brain region when determining the absolute CBV of the lesions.

• Research Organization: UCLA School of Medicine, Los Angeles, CA
• OSTI ID: 6590988
• Report Number(s): CONF-840619-
• Conference Information: Journal Name: J. Nucl. Med.; (United States) Journal Volume: 25:5
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
551001 -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
BLOOD FLOW
BLOOD-BRAIN BARRIER
BODY
BRAIN
CAT SCANNING
CENTRAL NERVOUS SYSTEM
COMPUTERIZED TOMOGRAPHY
CORRELATION FUNCTIONS
DIAGNOSTIC TECHNIQUES
DIFFUSION
DISEASES
DYNAMIC FUNCTION STUDIES
EMISSION COMPUTED TOMOGRAPHY
FUNCTIONS
MORPHOLOGY
NEOPLASMS
NERVOUS SYSTEM
ORGANS
PERMEABILITY
POSITRON COMPUTED TOMOGRAPHY
TOMOGRAPHY