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Dynamic PET studies of blood-brain barrier permeability in Alzheimer's disease

Conference · · J. Nucl. Med.; (United States)
OSTI ID:6719007
; ; ; ; ;
Alterations in blood-brain barrier (BBB) function may play an important role in Alzheimer's disease (AD), thus dynamic PET was used to quantitate the brain uptake of two radionuclides with low BBB permeability, Rb-82 and Ga-68 EDTA. Studies were performed on subjects meeting current research criteria for AD as well as healthy aged controls. Dynamic tomograhic data were collected using the Donner 280-crystal tomograph for 5 min with Rb-82 (N=10) and 30 min for Ga-68 EDTA (N=7), and analyzed using a two compartment model and a nonlinear least-squares fitting procedure for quantitation of the passage of isotope from blood to brain (k1). For both Rb-82 and Ga-68 EDTA studies kl values were not significantly different from zero. There were no significant differences between groups and the permeability of the barrier was not greater in temporal cortex, the region of neocortex most heavily involved in AD.
Research Organization:
VA Medical Center, Martinez, CA
OSTI ID:
6719007
Report Number(s):
CONF-850611-
Conference Information:
Journal Name: J. Nucl. Med.; (United States) Journal Volume: 26:5
Country of Publication:
United States
Language:
English

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Related Subjects

550602* -- Medicine-- External Radiation in Diagnostics-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ALKALI METAL ISOTOPES
AMINO ACIDS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BLOOD FLOW
BLOOD-BRAIN BARRIER
BODY
BRAIN
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM
CHELATING AGENTS
COMPARATIVE EVALUATIONS
COMPUTERIZED TOMOGRAPHY
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DISEASES
DRUGS
EDTA
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
GALLIUM 68
GALLIUM ISOTOPES
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOTOPES
LABELLED COMPOUNDS
LEAST SQUARE FIT
MAXIMUM-LIKELIHOOD FIT
MINUTES LIVING RADIOISOTOPES
NERVOUS SYSTEM
NERVOUS SYSTEM DISEASES
NUCLEI
NUMERICAL SOLUTION
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PERMEABILITY
POSITRON COMPUTED TOMOGRAPHY
RADIOISOTOPES
RADIOPHARMACEUTICALS
RUBIDIUM 82
RUBIDIUM ISOTOPES
SENSITIVITY
TOMOGRAPHY
TRANSPORT
UPTAKE
USES