Evaluation of blood-brain barrier permeability changes in rhesus monkeys and man using 82Rb and positron emission tomography

Journal Article · Tue Dec 01 04:00:00 EST 1981 · J. Comput. Assist. Tomogr.; (United States)

DOI:https://doi.org/10.1097/00004728-198112000-00002· OSTI ID:5367935

Yen, C K; Budinger, T F

Dynamic positron tomography of the brain with /sup 82/Rb, obtained from a portable generator (/sup 82/Sr (25 days) - /sup 82/Rb (76 sec)), provides a means of studying blood-brain barrier (BBB) permeability in physiological and clinical investigations. The BBB in rhesus monkeys was opened unilaterally be intracarotid infusion of 3 M urea. This osmotic barrier opening allowed entry into the brain of intravenously administered rubidium chloride. The BBB opening was demonstrated noninvasively using /sup 82/Rb and positron emission tomography and corroborated by the accumulation of /sup 86/Rb in tissue samples. Positron emission tomography studies can be repeated every 5 min and indicate that dynamic tomography or static imaging can be used to study BBB permeability changes induced by a wide variety of noxious stimuli. Brain tumors in human subjects are readily detected because of the usual BBB permeability disruption in and around the tumors.

• Research Organization: Donner Laboratory, University of California, Berkeley
• OSTI ID: 5367935
• Journal Information: J. Comput. Assist. Tomogr.; (United States), Journal Name: J. Comput. Assist. Tomogr.; (United States) Vol. 5:6; ISSN JCATD
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ALKALI METAL ISOTOPES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BLOOD-BRAIN BARRIER
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
COMPUTERIZED TOMOGRAPHY
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MACACUS
MAMMALS
MINUTES LIVING RADIOISOTOPES
MONKEYS
NEOPLASMS
NERVOUS SYSTEM
NUCLEI
ODD-ODD NUCLEI
ORGANS
PATHOLOGY
PATIENTS
PERMEABILITY
PHYSIOLOGY
POSITRON COMPUTED TOMOGRAPHY
PRIMATES
RADIOISOTOPES
RUBIDIUM 82
RUBIDIUM 86
RUBIDIUM ISOTOPES
STIMULI
TOMOGRAPHY
USES
VERTEBRATES